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Contents
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Week 1: |
Title: The molecules of Life • Structure and functions of DNA • Structure and functions of RNA • Structure and functions of Protein
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Week 2: |
Title: The central dogma of biology • Replication • Transcription • Translation
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Week 3: |
Title: The universe at nanoscale • General perspectives of biotechnology • General perspectives of nanotechnology • Intersection of biotechnology and nanotechnology: nanobiotechnology
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Week 4: |
Title: Field trip to Sabanci University Nanotechnology Research and Application Centre
• Clean room facility; information on lithography techniques • Nanoparticle synthesis and characterization infrastructure • Microscopy facilities • Nanobiotechnology laboratory
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Week 5: |
Title: Carbon based nanomaterials • Giant carbon materials • Fullerene • Graphene • Carbon nanotubes
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Week 6: |
Title: Metallic nanomaterials • Gold nanoparticles • Silver nanoparticles • Iron (oxide) nanoparticles
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Week 7: |
Title: Fluorescent nanomaterials • The concept of fluorescense • Quantum dots (down conversion nanoparticles) • Upconversion nanoparticles
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Week 8: |
Midterm exam |
Week 9: |
Title: Affinity probes for nanoparticle surface modification • Antibodies (protein based affinity probes) • Aptamers (DNA/RNA based synthetic affinity probes)
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Week 10: |
Title: Surface bio-modification (labelling) techniques • Carbodiimide chemistry • Streptavidin-Biotin interaction • Gold-thiol interaction • Ni/Co His-tag interaction
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Week 11: |
Title: Characterization of surface bio-modification-1 • Gel electrophoresis techniques • UV-Vis spectrophotometry
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Week 12: |
Title: Characterization of surface bio-modification-2 • Dynamic Light Scattering • Circular dichroism
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Week 13: |
Title: Sensing, imaging and drug delivery applications of nanoparticles • Interactive review of the recent literature in nanobiotechnology field • Discussion of the limitations of the nanomaterials • Watching and discussing the recent documentaries in the field
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Week 14: |
Title: Nanotoxicity and review of the course materials • Importance of nanomaterials’s size, shape and surface properties in biology • Quizz
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Week 15*: |
• Review of the course materials/final exam preparation week |
Week 16*: |
Final exam |
Textbooks and materials: |
• Nanobiotechnology: Concepts, Applications, and Perspectives. Christof M. Niemeyer (Editor) and Chad A. Mirkin (Editor), ISBN: 978-3-527-30658-9 • The Nanobiotechnology Handbook, Yubing Xie, ISBN 9781439838693 • Nanobiosensors, Volume 8, 1st Edition, Editors: Alexandru Grumezescu Hardcover ISBN: 9780128043011
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Recommended readings: |
• http://www.nature.com/nnano/focus/plenty-of-room/index.html • Feynman, R. P. Engineering and Science 22–36 (February 1960). • Feynman, R. P., Leighton, R. B. & Sands, M. Feynman Lectures on Physics (Vols 1–3) (Addison Wesley, 1963). • Feynman, R. P. 'Surely You're Joking, Mr Feynman!' Adventures of a Curious Character (W. W. Norton, 1985). • Toumey, C. Engineering and Science 16–23 (June 2005).
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* Between 15th and 16th weeks is there a free week for students to prepare for final exam.
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