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Syllabus ( MBG 324 )


   Basic information
Course title: Molecular Genetics II
Course code: MBG 324
Lecturer: Prof. Dr. Uygar Halis TAZEBAY
ECTS credits: 5
GTU credits: 3 (3+0+0)
Year, Semester: 3, Spring
Level of course: First Cycle (Undergraduate)
Type of course: Compulsory
Language of instruction: English
Mode of delivery: Face to face
Pre- and co-requisites: MBG 222 Molecular Genetics I
Professional practice: No
Purpose of the course: The objective of this course is to provide an overview of transciption, translation, regulation of gene expression and epigenetic mechanisms.
   Learning outcomes Up

Upon successful completion of this course, students will be able to:

  1. Explain how a gene is expressed in the cell and how this expression can be regulated at different points and levels by multiple molecular mechanisms.

    Contribution to Program Outcomes

    1. To be able to define general concepts and problems related to Molecular Biology and Genetics and to produce solutions.
    2. To be able to define the structure-function relationship at the molecular level in cells and organisms.

    Method of assessment

    1. Written exam
  2. Explain the distinct molecular mechanisms underlying the epigenetic processes.

    Contribution to Program Outcomes

    1. To be able to define general concepts and problems related to Molecular Biology and Genetics and to produce solutions.
    2. To be able to define the structure-function relationship at the molecular level in cells and organisms.
    3. To be able to define life forms and their relationship with their environment.

    Method of assessment

    1. Written exam
  3. Analyze and discuss the scientific data obtained from original research in the area of molecular genetics.

    Contribution to Program Outcomes

    1. To be able to define life forms and their relationship with their environment.
    2. To be able to present their studies in scientific talks and written texts in national and international scientific platforms by a foreign language.

    Method of assessment

    1. Homework assignment
   Contents Up
Week 1: Genetic information, nucleic acids, mutations
Week 2: Exons and introns, gene families
Week 3: Genome structure, organelle genomes
Week 4: RNA forms, ribosomes
Week 5: Translation, translational control
Week 6: Posttranslational modifications
Week 7: RNA polymerases, promoters, enhancers
Week 8: Transcription
Week 9: Transciption factors, DNA-protein interactions
Midterm exam
Week 10: Chromatin remodeling, nucleosomes
Week 11: Histone modifications, DNA methylation
Week 12: Epigenetic processes
Week 13: Transcriptional control during cell differentiation
Week 14: Tissue specific gene expression
Week 15*: General review
Week 16*: Final exam
Textbooks and materials: Genes IX. Lewin, B. 9th ed. 2008. Jones and Bartlett Publishers.
Recommended readings: 1. Molecular Biology of the Gene. Watson, J.D. et al. 6th ed. 2007. Benjamin Cummings. 2. Molecular Cell Biology. Lodish, H. et al. 6th ed. 2007. W.H. Freeman and Company.
  * Between 15th and 16th weeks is there a free week for students to prepare for final exam.
Assessment Up
Method of assessment Week number Weight (%)
Mid-terms: 9 30
Other in-term studies: 0
Project: 0
Homework: 13, 14 20
Quiz: 0
Final exam: 16 50
  Total weight:
(%)
   Workload Up
Activity Duration (Hours per week) Total number of weeks Total hours in term
Courses (Face-to-face teaching): 3 14
Own studies outside class: 3 14
Practice, Recitation: 0 0
Homework: 4 2
Term project: 0 0
Term project presentation: 0 0
Quiz: 0 0
Own study for mid-term exam: 2 8
Mid-term: 2 1
Personal studies for final exam: 1 14
Final exam: 2 1
    Total workload:
    Total ECTS credits:
*
  * ECTS credit is calculated by dividing total workload by 25.
(1 ECTS = 25 work hours)
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