Syllabus ( MBG 324 )
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Basic information
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Course title: |
Molecular Genetics II |
Course code: |
MBG 324 |
Lecturer: |
Prof. Dr. Uygar Halis TAZEBAY
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ECTS credits: |
5 |
GTU credits: |
3 (3+0+0) |
Year, Semester: |
3, Spring |
Level of course: |
First Cycle (Undergraduate) |
Type of course: |
Compulsory
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Language of instruction: |
English
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Mode of delivery: |
Face to face
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Pre- and co-requisites: |
MBG 222 Molecular Genetics I |
Professional practice: |
No |
Purpose of the course: |
The objective of this course is to provide an overview of transciption, translation, regulation of gene expression and epigenetic mechanisms. |
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Learning outcomes
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Upon successful completion of this course, students will be able to:
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Explain how a gene is expressed in the cell and how this expression can be regulated at different points and levels by multiple molecular mechanisms.
Contribution to Program Outcomes
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To be able to define general concepts and problems related to Molecular Biology and Genetics and to produce solutions.
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To be able to define the structure-function relationship at the molecular level in cells and organisms.
Method of assessment
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Written exam
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Explain the distinct molecular mechanisms underlying the epigenetic processes.
Contribution to Program Outcomes
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To be able to define general concepts and problems related to Molecular Biology and Genetics and to produce solutions.
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To be able to define the structure-function relationship at the molecular level in cells and organisms.
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To be able to define life forms and their relationship with their environment.
Method of assessment
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Written exam
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Analyze and discuss the scientific data obtained from original research in the area of molecular genetics.
Contribution to Program Outcomes
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To be able to define life forms and their relationship with their environment.
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To be able to present their studies in scientific talks and written texts in national and international scientific platforms by a foreign language.
Method of assessment
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Homework assignment
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Contents
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Week 1: |
Genetic information, nucleic acids, mutations |
Week 2: |
Exons and introns, gene families |
Week 3: |
Genome structure, organelle genomes |
Week 4: |
RNA forms, ribosomes |
Week 5: |
Translation, translational control |
Week 6: |
Posttranslational modifications |
Week 7: |
RNA polymerases, promoters, enhancers |
Week 8: |
Transcription |
Week 9: |
Transciption factors, DNA-protein interactions Midterm exam |
Week 10: |
Chromatin remodeling, nucleosomes |
Week 11: |
Histone modifications, DNA methylation |
Week 12: |
Epigenetic processes |
Week 13: |
Transcriptional control during cell differentiation |
Week 14: |
Tissue specific gene expression |
Week 15*: |
General review |
Week 16*: |
Final exam |
Textbooks and materials: |
Genes IX. Lewin, B. 9th ed. 2008. Jones and Bartlett Publishers. |
Recommended readings: |
1. Molecular Biology of the Gene. Watson, J.D. et al. 6th ed. 2007. Benjamin Cummings. 2. Molecular Cell Biology. Lodish, H. et al. 6th ed. 2007. W.H. Freeman and Company. |
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* Between 15th and 16th weeks is there a free week for students to prepare for final exam.
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Assessment
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Method of assessment |
Week number |
Weight (%) |
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Mid-terms: |
9 |
30 |
Other in-term studies: |
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0 |
Project: |
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0 |
Homework: |
13, 14 |
20 |
Quiz: |
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0 |
Final exam: |
16 |
50 |
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Total weight: |
(%) |
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Workload
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Activity |
Duration (Hours per week) |
Total number of weeks |
Total hours in term |
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Courses (Face-to-face teaching): |
3 |
14 |
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Own studies outside class: |
3 |
14 |
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Practice, Recitation: |
0 |
0 |
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Homework: |
4 |
2 |
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Term project: |
0 |
0 |
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Term project presentation: |
0 |
0 |
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Quiz: |
0 |
0 |
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Own study for mid-term exam: |
2 |
8 |
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Mid-term: |
2 |
1 |
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Personal studies for final exam: |
1 |
14 |
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Final exam: |
2 |
1 |
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Total workload: |
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Total ECTS credits: |
* |
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* ECTS credit is calculated by dividing total workload by 25. (1 ECTS = 25 work hours)
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