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Syllabus ( MBG 331 )

   Basic information
Course title: Molecular Cell Biology I
Course code: MBG 331
Lecturer: Prof. Dr. Ferruh ÖZCAN
ECTS credits: 5
GTU credits: 3 (3+0+0)
Year, Semester: 3, Fall
Level of course: First Cycle (Undergraduate)
Type of course: Compulsory
Language of instruction: English
Mode of delivery: Face to face
Pre- and co-requisites: MBG 111
Professional practice: No
Purpose of the course: Teach the chemical and physical foundation of prokaryotic and eukaryotic cells; the high throughput techniques such as proteomics, transcriptomics, and genomics used frequently in molecular biology; how the cells produce and consume energy to maintain and propagate their life; the structure and the organization of the genome and the functional protein assemblies; the concepts of various complex biological processes including apoptosis, cellular differentiation and proliferation, protein, DNA and RNA synthesis and processing.
   Learning outcomes Up

Upon successful completion of this course, students will be able to:

  1. Apply his/her advanced knowlodge on selected topics such as cellular organization, communication and basic genetic mechanisms, to produce solutions to hands on problems in related fields like cancer, genetic and metabolic diseases, development and etc.,

    Contribution to Program Outcomes

    1. To be able to explain the genetic information flow in organisms and populations.
    2. To be able to comprehend the history and nature of scientific thinking and to apply them to problems in the field.
    3. To be able to present their studies in scientific talks and written texts in national and international scientific platforms by a foreign language.

    Method of assessment

    1. Written exam
  2. Analyze and critique original research articles in Molecular Cell Biology and related topic

    Contribution to Program Outcomes

    1. To be able to understand the relationship between matter and energy in organisms.
    2. To be able to define the structure-function relationship at the molecular level in cells and organisms.
    3. To be able to explain the genetic information flow in organisms and populations.
    4. To be able to follow current scientific and technological innovations with the awareness of continuous learning and to apply them in the field.

    Method of assessment

    1. Homework assignment
  3. Explain how extracellular and intracellular signals activate and repress the cellular genes and biosynthetic pathways

    Contribution to Program Outcomes

    1. To be able to understand the relationship between matter and energy in organisms.
    2. To be able to define the structure-function relationship at the molecular level in cells and organisms.
    3. To be able to explain the genetic information flow in organisms and populations.
    4. To be able to drive hypotheses using existing knowledge, designing and conducting experiment for problem solving and make correct interpretation of the results obtained from the experiment.

    Method of assessment

    1. Written exam
   Contents Up
Week 1: Cell and Genom; Cell chemistry and biosynthesis; Proteins
Week 2: Basic Genetic Mechanisms: Chromosomal DNA and packaging in the form of chromatin structure; General structural properties of chromosomes
Week 3: DNA Replication, Repair and Recombination: Conservation of DNA sequences and Genetic Recombination
Week 4: Expression of Cellular Genome: From DNA to Protein: Control of Gene Expression; Overview of Genetic Control
Week 5: How Genetic Switches Work; Post-translational Control; How Genom evolved
Week 6: Basic Techniques Used in Molecular Cell Biology: Separation of the cells, growth in the culture, DNA isolation, cloning and sequencing Examining the structure and function of protins
Week 7: Mid-term Exam
Week 8: İntracellular Organization, Structure of cell membrane, lipid bilayer and mebrane proteins
Week 9: Transport of small molecules from cell mebrane and electrical features of the mebranes
Week 10: Partition of the cells, tarnsportation between nucleus and cytosol, transport of proteins into mitochondria and chloroplasts
Week 11: Organelles, peroxisome, endoplasmic reticulum, golgi apparatus, sending proteins to work addresses, vesicles traffic, endocytosis and exocytosis
Week 12: Energy conservation: Mitochondria and chloroplast
Week 13: Cellular Communication: General principles of cellular communication and Cellular signal transduction
Week 14: Signal trunsduction with G-protein coupled cell surface receptors
Week 15*: Signal trunsduction with enzyme associated cell surface receptors; signaling pathways linked to regulatable protein degradation; signalling pathways in plats
Week 16*: Final exam
Textbooks and materials: Molecular Biology of the Cell. Alberts, B. et al. 7th edition, 2022. Garland Science.
Recommended readings: Cell and Molecular Biology by Gerald Karp. 2007. John Wiley Inc.
Molecular Cell Biology. Lodish, H. et al. 5th ed. 2004. W.H. Freeman and Company.
Developmental Biology by Scott F. Gilbert. 8th ed. 2006. Sinauer Assoc.
  * Between 15th and 16th weeks is there a free week for students to prepare for final exam.
Assessment Up
Method of assessment Week number Weight (%)
Mid-terms: 7 40
Other in-term studies: 0 0
Project: 0 0
Homework: 0 0
Quiz: 0 0
Final exam: 16 60
  Total weight:
(%)
   Workload Up
Activity Duration (Hours per week) Total number of weeks Total hours in term
Courses (Face-to-face teaching): 3 14
Own studies outside class: 2 16
Practice, Recitation: 0 0
Homework: 2 6
Term project: 0 0
Term project presentation: 0 0
Quiz: 6 5
Own study for mid-term exam: 0 0
Mid-term: 3 1
Personal studies for final exam: 0 0
Final exam: 3 1
    Total workload:
    Total ECTS credits:
*
  * ECTS credit is calculated by dividing total workload by 25.
(1 ECTS = 25 work hours)
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