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Syllabus ( MBG 432 )

   Basic information
Course title: Molecular Immunology
Course code: MBG 432
Lecturer: Prof. Dr. Tamer YAĞCI
ECTS credits: 5
GTU credits: 3 (3+0+0)
Year, Semester: 4, Fall
Level of course: First Cycle (Undergraduate)
Type of course: Departmental Elective
Language of instruction: English
Mode of delivery: Face to face
Pre- and co-requisites: Knowledge of Scientific English at a level that allows the students to write and understand the scientific publications
Professional practice: No
Purpose of the course: To lead students to gain below outcomes;
1: will have information about the tissues and cells of the immune system,
2: know mechanisms of the innate and adaptive immunity,
3: have knowledge about integration of the cellular and humoral immunities against pathogens that invade our organisms, molecular bases of the antigen processing and antigen presentation to the immune system.
4: This basic knowledge will allow students to better understand topics such as diseases of the immune system, transplantation, allergy and tumor immunology.
   Learning outcomes Up

Upon successful completion of this course, students will be able to:

  1. Define cells and tissues of the immune system and effector mechanisms of innate and adaptive immuniies.

    Contribution to Program Outcomes

    1. To be able to define general concepts and problems related to Molecular Biology and Genetics and to produce solutions.
    2. To be able to define the structure-function relationship at the molecular level in cells and organisms.
    3. To be able to explain the genetic information flow in organisms and populations.
    4. To be able to define life forms and their relationship with their environment.
    5. To be able to drive hypotheses using existing knowledge, designing and conducting experiment for problem solving and make correct interpretation of the results obtained from the experiment.
    6. To be able to apply biological concepts to individual, social, economic, technologic and environmental issues and to develop sustainable approaches for problem solving.

    Method of assessment

    1. Written exam
  2. Distinguish differential processing of intracellular and extracellular antigens and their activation of distinct subsets of T cells by MHC class I and MHC class II molecules.

    Contribution to Program Outcomes

    1. To be able to define the structure-function relationship at the molecular level in cells and organisms.
    2. To be able to explain the genetic information flow in organisms and populations.
    3. To be able to apply biological concepts to individual, social, economic, technologic and environmental issues and to develop sustainable approaches for problem solving.

    Method of assessment

    1. Written exam
  3. Explain development of T and B cells and the mechanisms of cellular and humoral immunities.

    Contribution to Program Outcomes

    1. To be able to define the structure-function relationship at the molecular level in cells and organisms.
    2. To be able to explain the genetic information flow in organisms and populations.
    3. To be able to drive hypotheses using existing knowledge, designing and conducting experiment for problem solving and make correct interpretation of the results obtained from the experiment.
    4. To be able to apply biological concepts to individual, social, economic, technologic and environmental issues and to develop sustainable approaches for problem solving.

    Method of assessment

    1. Written exam
   Contents Up
Week 1: Basic concepts in immunology. The bases of innate and adaptive immunity.
Week 2: Cells and tissues of the immune system
Week 3: Circulation of cells of the immune system and theri migration into tissues.
Week 4: Innate immunity: cellular abd soluble sensors and effector molecules. Inflammation and anti-viral response. Complement system.
Week 5: Antigens and antibodies. Structure-function relationship of antibodies. The chemistry of antigen-antibody binding.
Week 6: Antigen processing in MHC Class I and II pathways. Functions of MHC Complex. Prsentation of antigens to T cells.
Week 7: Signaling through immune system and cytokine receptors
Week 8: Development of B and T lymphocytes. Mechanisms of rearrangement of antigen receptors.
Week 9: Midterm exam
Week 10: Activation of T cells. Activating signals and functional responses.
Week 11: Differentiation and functions of CD4 and CD8 T cells. Properties of effector T cells. T Cell-dependent cytotoxicity.
Week 12: Activation of B cells and antibody production.
Week 13: Humaral immune responses. Functions of antibody isotypes.
Week 14: Structure of mucosal immune system.and mucosal immune responses against pathogens.
Week 15*: General Assessment
Week 16*: Final Exam
Textbooks and materials: Abul K. Abbas, Andrew H. Lichtman, & Shiv Pillai. Cellular and Molecular Immunology, 10th. edition Elsevier (2022) ISBN: 978-0-323-75749-2
Recommended readings: Murphy K, Travers P, Walport M. Immunobiology 9th edition Garland Science (2016) ISBN 978-0-8153-4551-0
  * Between 15th and 16th weeks is there a free week for students to prepare for final exam.
Assessment Up
Method of assessment Week number Weight (%)
Mid-terms: 8 40
Other in-term studies: 0
Project: 0
Homework: 0
Quiz: 0
Final exam: 16 60
  Total weight:
(%)
   Workload Up
Activity Duration (Hours per week) Total number of weeks Total hours in term
Courses (Face-to-face teaching): 3 14
Own studies outside class: 3 14
Practice, Recitation: 0 0
Homework: 0 0
Term project: 0 0
Term project presentation: 0 0
Quiz: 0 0
Own study for mid-term exam: 15 1
Mid-term: 3 1
Personal studies for final exam: 15 1
Final exam: 3 1
    Total workload:
    Total ECTS credits:
*
  * ECTS credit is calculated by dividing total workload by 25.
(1 ECTS = 25 work hours)
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