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Syllabus ( MBG 438 )

   Basic information
Course title: Immunopathology
Course code: MBG 438
Lecturer: Prof. Dr. Tamer YAĞCI
ECTS credits: 5
GTU credits: 3 (3+0+0)
Year, Semester: 4, Spring
Level of course: First Cycle (Undergraduate)
Type of course: Departmental Elective
Language of instruction: English
Mode of delivery: Face to face
Pre- and co-requisites: MBG 432 Molecular Immunology
Professional practice: No
Purpose of the course: Students attending this course will:
-Review effector mechanisms of cell-mediated and humoral immunity
-Know inherited and acquired immune deficiency diseases.
-Grasp molecular and cellular mechanisms of allergy and hypersensitivity reactions.
-Understand pathogenic mechanisms, genetic and enviromental factors that lead to autoimmune diseases.
-Be familiar with prevention of unwanted immune responses by drugs, development of effective vaccination strategies and exploitation of immune system against tumors.
   Learning outcomes Up

Upon successful completion of this course, students will be able to:

  1. Explain main causes of inherited and acquired immune deficiencies

    Contribution to Program Outcomes

    1. To be able to define general concepts and problems related to Molecular Biology and Genetics and to produce solutions.
    2. To be able to define the structure-function relationship at the molecular level in cells and organisms.
    3. To be able to explain the genetic information flow in organisms and populations.
    4. To be able to drive hypotheses using existing knowledge, designing and conducting experiment for problem solving and make correct interpretation of the results obtained from the experiment.
    5. To be able to apply biological concepts to individual, social, economic, technologic and environmental issues and to develop sustainable approaches for problem solving.

    Method of assessment

    1. Written exam
  2. Distinguish molecular and cellular mechanisms between different types of allergic and hypersensitivity reactions

    Contribution to Program Outcomes

    1. To be able to define the structure-function relationship at the molecular level in cells and organisms.
    2. To be able to drive hypotheses using existing knowledge, designing and conducting experiment for problem solving and make correct interpretation of the results obtained from the experiment.
    3. To be able to apply biological concepts to individual, social, economic, technologic and environmental issues and to develop sustainable approaches for problem solving.

    Method of assessment

    1. Written exam
  3. Apply his/her knowledge on transplantation, tumor immunology and vaccination strategies to develop innovative projects and to design experiments.

    Contribution to Program Outcomes

    1. To be able to define general concepts and problems related to Molecular Biology and Genetics and to produce solutions.
    2. To be able to define the structure-function relationship at the molecular level in cells and organisms.
    3. To be able to drive hypotheses using existing knowledge, designing and conducting experiment for problem solving and make correct interpretation of the results obtained from the experiment.
    4. To be able to apply biological concepts to individual, social, economic, technologic and environmental issues and to develop sustainable approaches for problem solving.

    Method of assessment

    1. Written exam
   Contents Up
Week 1: Immunologic tolerance and mechanisms of autoimmunity
Week 2: Immunity to microbes
Week 3: Strategies for vaccine development
Week 4: Transplantation immunology
Week 5: Blood groups; blood transfusion. Transplantation of hematopoetic stem cells
Week 6: Tumor immunology
Week 7: Immunotherapeutic strategies in cancer.
Week 8: Midterm Exam
Week 9: Hypersensitvity gisorders. Non-IgE antibodies and T-cell mediated hypersensitivities.
Week 10: Patogenesis and therapeutic strategies in immunologic diseases: SLE, MS, Rheumatoiid arthritis, Type I diabetes mellitus.
Week 11: Allergic diseases. Genetic susceptibility, pathogenesis and therapies.
Week 12: Congenital immunodeficiencies.
Week 13: The biology of HIV and AIDS problem.
Week 14: Revision
Week 15*: Final assessment of the course
Week 16*: Final exam
Textbooks and materials: Abul K. Abbas, Andrew H. Lichtman, & Shiv Pillai. Cellular and Molecular Immunology, 10th. edition Elsevier (2022) ISBN: 978-0-323-75749-2
Recommended readings: Murphy K, Travers P, Walport M. Immunobiology 9th edition Garland Science (2016) ISBN 978-0-8153-4551-0
  * Between 15th and 16th weeks is there a free week for students to prepare for final exam.
Assessment Up
Method of assessment Week number Weight (%)
Mid-terms: 8 40
Other in-term studies: 0
Project: 0
Homework: 0
Quiz: 0
Final exam: 16 60
  Total weight:
(%)
   Workload Up
Activity Duration (Hours per week) Total number of weeks Total hours in term
Courses (Face-to-face teaching): 3 14
Own studies outside class: 3 14
Practice, Recitation: 0 0
Homework: 0 0
Term project: 0 0
Term project presentation: 0 0
Quiz: 0 0
Own study for mid-term exam: 15 1
Mid-term: 3 1
Personal studies for final exam: 15 1
Final exam: 3 1
    Total workload:
    Total ECTS credits:
*
  * ECTS credit is calculated by dividing total workload by 25.
(1 ECTS = 25 work hours)
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