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Syllabus ( MBG 445 )


   Basic information
Course title: Introduction to Synthetic Biology
Course code: MBG 445
Lecturer: Assoc. Prof. Dr. Özlem AKKAYA
ECTS credits: 5
GTU credits: 3 (3-0-0)
Year, Semester: 2022-2023, Fall
Level of course: First Cycle (Undergraduate)
Type of course: Elective
Language of instruction: English
Mode of delivery: Face to face , Group study
Pre- and co-requisites: none
Professional practice: No
Purpose of the course: The overall goal of the course is to introduce to students with the important methods, strategies and applications of synthetic biology which is one of the most promising new technologies.
   Learning outcomes Up

Upon successful completion of this course, students will be able to:

  1. Define synthetic biology and understand its importance in this century

    Contribution to Program Outcomes

    1. To be able to define general concepts and problems related to Molecular Biology and Genetics and to produce solutions.
    2. To be able to comprehend the history and nature of scientific thinking and to apply them to problems in the field.
    3. To be able to work individually, make independent decisions and participate actively in multidisciplinary group studies.
    4. To be able to follow current scientific and technological innovations with the awareness of continuous learning and to apply them in the field.

    Method of assessment

    1. Written exam
    2. Homework assignment
  2. Understand fundamental concepts, principles and methods of synthetic biology

    Contribution to Program Outcomes

    1. To be able to define general concepts and problems related to Molecular Biology and Genetics and to produce solutions.
    2. To be able to follow current scientific and technological innovations with the awareness of continuous learning and to apply them in the field.

    Method of assessment

    1. Written exam
  3. Introduce key questions of ethics and biosafety on the responsible use of this new technology

    Contribution to Program Outcomes

    1. To be able to work individually, make independent decisions and participate actively in multidisciplinary group studies.
    2. To be able to embrace academic ethical rules and to be able to act with a sense of responsibility.

    Method of assessment

    1. Written exam
    2. Homework assignment
   Contents Up
Week 1: What is Synthetic Biology?
Week 2: The emergence of synthetic biology
Week 3: Fundamentals of DNA Engineering
-BioBricks and Standard Biological Parts
Week 4: Fundamentals of biodesing from biological parts to genetic circuits
Week 5: Synthetic biology and bioengineering
Week 6: Synthetic biology and genom editing
Week 7: Midterm exam
Week 8: Synthetic biology and chassis engineering
Week 9: Synthetic biology and metabolic engineering
Week 10: Social and ethical perspectives in synthetic biology
Week 11: Applications of synthetic biology
Week 12: iGEM Projects-1
Week 13: iGEM Projects-2
Week 14: iGEM Projects-3
Week 15*: General overview
Week 16*: Final exam
Textbooks and materials:
Recommended readings: Porcar, M., & Peretó, J. (2014). Synthetic biology: from iGEM to the artificial cell. Springer Netherlands.
Kuldell, N., Bernstein, R., Ingram, K., & Hart, K. M. (2015). BioBuilder: Synthetic biology in the lab. O'Reilly.
Baldwin, G. (2012). Synthetic biology: A primer. John Wiley & Sons.
Church, G. M., & Regis, E. (2014). Regenesis: how synthetic biology will reinvent nature and ourselves. Basic Books.
  * Between 15th and 16th weeks is there a free week for students to prepare for final exam.
Assessment Up
Method of assessment Week number Weight (%)
Mid-terms: 7 25
Other in-term studies: 0 0
Project: 0 0
Homework: 15 25
Quiz: 0 0
Final exam: 16 50
  Total weight:
(%)
   Workload Up
Activity Duration (Hours per week) Total number of weeks Total hours in term
Courses (Face-to-face teaching): 3 14
Own studies outside class: 3 14
Practice, Recitation: 0 0
Homework: 20 1
Term project: 0 0
Term project presentation: 0 0
Quiz: 0 0
Own study for mid-term exam: 8 1
Mid-term: 3 1
Personal studies for final exam: 10 1
Final exam: 3 1
    Total workload:
    Total ECTS credits:
*
  * ECTS credit is calculated by dividing total workload by 25.
(1 ECTS = 25 work hours)
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