• Basic information
• Learning outcomes
• Contents
• Assessment
• Workload

Learning outcomes

Upon successful completion of this course, students will be able to:

1. Explain protein translation in eukaryotic and prokaryotic cells.

   Contribution to Program Outcomes

   1. Define and manipulate advanced concepts of Biology
   2. Critically review the literature pertaining to his/her research projects, and connect the earlier literature to his/her own results,
   3. Identify structure-function relationships in cells and organisms
   4. Acquire scientific knowledge and work independently,
   5. Effectively express his/her research ideas and findings both orally and in writing
   6. Understand the importance of identification, utilization and maintenance of the biological diversity in the country.

   Method of assessment

   1. Written exam
2. Grasp the mechanisms which target proteins to a number of compartments, the major posttranslational modifications occurring throughout the secretory pathway, and the basis of the molecular specificity of vesicular transport.

   Contribution to Program Outcomes

   1. Define and manipulate advanced concepts of Biology
   2. Critically review the literature pertaining to his/her research projects, and connect the earlier literature to his/her own results,
   3. Identify structure-function relationships in cells and organisms
   4. Acquire scientific knowledge and work independently,
   5. Effectively express his/her research ideas and findings both orally and in writing

   Method of assessment

   1. Seminar/presentation
   2. Term paper
3. Build up knowledge about the different protein degradation mechanisms.

   Contribution to Program Outcomes

   1. Define and manipulate advanced concepts of Biology
   2. Critically review the literature pertaining to his/her research projects, and connect the earlier literature to his/her own results,
   3. Identify structure-function relationships in cells and organisms
   4. Acquire scientific knowledge and work independently,
   5. Effectively express his/her research ideas and findings both orally and in writing

   Method of assessment

   1. Written exam
   2. Seminar/presentation
4. Have knowledge about how specific eukaryotic proteins are targeted to plasma to membrane, extracellular matrix or cell wall, ER, vacuole, golgi, chloroplast, mitochondria, nucleus and cytoplasm.

   Contribution to Program Outcomes

   1. Define and manipulate advanced concepts of Biology
   2. Identify structure-function relationships in cells and organisms

   Method of assessment

   1. Written exam

Contents
Week 1:	Protein Synthesis in Prokaryotes
Week 2:	Protein Synthesis in Prokaryotes
Week 3:	Protein Folding: Chaperon Systems I.
Week 4:	Synthesis and Localization of Lyzosomal and Membrane Proteins
Week 5:	Protein Modifications and Quality control in Endoplasmic Reticulum
Week 6:	. Vesicular Transport Mechanism
Week 7:	. Midterm Exam
Week 8:	Protein Transport in Bacteria
Week 9:	Targeting of Chloroplast and MitochondrialProteins.
Week 10:	Nuclear Import and Export of Proteins.
Week 11:	Targeting of Peroxisomal Proteins
Week 12:	Ubiquitin-Mediated Degradation: Ubiquitination, Degradation of Ubiquitinated Proteins, Proteasomes
Week 13:	.Protein Degradation: Proteases
Week 14:	Term Paper Presentation
Week 15*:	General review.
Week 16*:	Final exam
Textbooks and materials:	Protein targeting, transport & translocation edited by Ross E. Dalbey, Gunnar von Heijne.
Recommended readings:	1.Protein biotechnology / Gary Walsh, Denis R. Headon 2.Structure and mechanism in protein science : a guide to enzyme catalysis and protein folding ,1999 / Alan Fersht. 3.Guidebook to the molecular chaperones and protein-folding catalysts,1997 / edited by Mary-Jane Gething 4.Molecular Cell Biology ,1995/ Lodish, et al. 5.Introduction to protein structure,1999 / Carl Branden, John Tooze
	* Between 15th and 16th weeks is there a free week for students to prepare for final exam.

Assessment
Method of assessment	Week number	Weight (%)
Mid-terms:	7	25
Other in-term studies:	12	25
Project:	0	0
Homework:	14	10
Quiz:	0	0
Final exam:	16	40
	Total weight:	(%)

Workload
Activity	Duration (Hours per week)	Total number of weeks	Total hours in term
Courses (Face-to-face teaching):	3	14
Own studies outside class:	3	14
Practice, Recitation:	0	0
Homework:	6	10
Term project:	0	0
Term project presentation:	2	1
Quiz:	0	0
Own study for mid-term exam:	12	1
Mid-term:	1	1
Personal studies for final exam:	12	2
Final exam:	2	1
		Total workload:
		Total ECTS credits:	*
	* ECTS credit is calculated by dividing total workload by 25. (1 ECTS = 25 work hours)