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Syllabus ( MBG 635 )

   Basic information
Course title: Molecular Cell Biology
Course code: MBG 635
Lecturer: Prof. Dr. Ferruh ÖZCAN
ECTS credits: 7.5
GTU credits: 3 (3+0+0)
Year, Semester: 1/2, Fall and Spring
Level of course: Second Cycle (Master's)
Type of course: Area Elective
Language of instruction: English
Mode of delivery: Face to face
Pre- and co-requisites: None
Professional practice: No
Purpose of the course: Successful completion of the course will enable graduate students to:
gain comprehensive understanding of basic genetic mechanisms, cellular organization and communication.
carry out critical thinking and evaluation of the current literature pertinent to covered topics of Molecular and Cell Biology
participate in discussions on related current topics in Molecular and Cell Biology journal clubs and other scientific.
gain theoretical background to prepare scientific projects in the field of Molecular and Cell Biology.
   Learning outcomes Up

Upon successful completion of this course, students will be able to:

  1. Apply his/her advanced knowlodge on selected topics such as cellular organization, communication and basic genetic mechanisms, to produce solutions to hands on problems in related fields like cancer, genetic and metabolic diseases, development and etc.,

    Contribution to Program Outcomes

    1. Define and manipulate advanced concepts of Biology
    2. Critically review the literature pertaining to his/her research projects, and connect the earlier literature to his/her own results,
    3. Effectively express his/her research ideas and findings both orally and in writing

    Method of assessment

    1. Homework assignment
    2. Laboratory exercise/exam
  2. Analyze and critique original research articles in Molecular Cell Biology and related topics.

    Contribution to Program Outcomes

    1. Critically review the literature pertaining to his/her research projects, and connect the earlier literature to his/her own results,
    2. Acquire scientific knowledge and work independently,

    Method of assessment

    1. Written exam
  3. Explain how extracellular and intracellular signals activate and repress the cellular genes and biosynthetic pathways

    Contribution to Program Outcomes

    1. Define the relationship among life forms and their environments and ecosystems
    2. Develop an understanding of matter and energy in organisms

    Method of assessment

    1. Written exam
    2. Homework assignment
   Contents Up
Week 1: General principles of Cellular Communication
Week 2: Pathologies of Cellular Communication
Week 3: The Cytoskeleton and Cell Behavior
Week 4: Molecular Motors
Week 5: Components of The Cell Cycle Control System
Week 6: The molecular and celluar aspects of Cancer
Week 7: The molecular and celluar aspects of Apoptosis
Week 8: Midterm exam
Week 9: ECM receptors; İntegrins, Cadherins and Ig like CAMs
Week 10: Universal Mechanisms of Animal development in C. Elegans model
Week 11: Molecular genetics of pattern formation: body plan in Drosophila
Week 12: Hox Genes, Organogenesis and Patterning of Appendages
Week 13: The Mouse and Neural development
Week 14: Specialized Tissues and Stem Cells, Tissue Renewal
Week 15*: General review.
Week 16*: Final exam
Textbooks and materials:
Recommended readings: Molecular Biology of The Cell by Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, and Peter Walter, (2007), Garland Inc 6 edition. Developmental Biology by Scott F. Gilbert. Eight edition (2006) Sinauer Assoc. Cell and Molecular Biology by Gerald Karp. (2007) John Wiley Inc.
  * Between 15th and 16th weeks is there a free week for students to prepare for final exam.
Assessment Up
Method of assessment Week number Weight (%)
Mid-terms: 8 30
Other in-term studies: 0
Project: 0
Homework: 14 20
Quiz: 4, 5, 6, 9, 10, 11,12 10
Final exam: 16 40
  Total weight:
(%)
   Workload Up
Activity Duration (Hours per week) Total number of weeks Total hours in term
Courses (Face-to-face teaching): 3 14
Own studies outside class: 3 14
Practice, Recitation: 0 0
Homework: 6 10
Term project: 0 0
Term project presentation: 0 0
Quiz: 1 7
Own study for mid-term exam: 15 1
Mid-term: 1 1
Personal studies for final exam: 15 1
Final exam: 2 1
    Total workload:
    Total ECTS credits:
*
  * ECTS credit is calculated by dividing total workload by 25.
(1 ECTS = 25 work hours)
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