• Basic information
• Learning outcomes
• Contents
• Assessment
• Workload

Learning outcomes

Upon successful completion of this course, students will be able to:

1. 1. Understand the variety of biomolecules, their structures and functions while understanding the principle intermolecular forces that help these molecules to assemble.

   Contribution to Program Outcomes

   1. Başta biyoloji olmak üzere ilgili temel bilimlerde ve mühendislik alanlarında sağlam bir altyapıya sahip olmak
   2. Biyoteknolojide sektörün ihtiyaçlarını giderebilecek ve sorunlarını çözebilecek yaklaşımlar geliştirebilmek ve Ar-Ge faaliyetleri yürütebilmek

   Method of assessment

   1. Written exam
   2. Homework assignment
2. 2. Demonstrate an understanding of protein folding and techniques such as NMR and EM, that can be utilized to follow the acquisition or loss of folded conformations.

   Contribution to Program Outcomes

   1. Biyoteknolojide sektörün ihtiyaçlarını giderebilecek ve sorunlarını çözebilecek yaklaşımlar geliştirebilmek ve Ar-Ge faaliyetleri yürütebilmek
   2. Biyoteknoloji alanında girişimci olabilmek ve/veya yeni girişimlere gerek bilimsel ve teknik gerekse yönetsel katkı sağlayabilmek

   Method of assessment

   1. Written exam
   2. Homework assignment
3. 3. Understand how membrane proteins and enzymes work and develop understanding on their allosteric modulation mechanisms.

   Contribution to Program Outcomes

   1. Tez konusu ile ilgili biyoteknoloji alanında (sağlık biyoteknolojisi, bitki biyoteknolojisi, endüstriyel biyoteknoloji veya sentetik ve sistem biyoteknolojisi) üst düzey ve güncel bilgilere sahip olmak
   2. Sanayinin Ar-Ge faaliyetleri için gerekli teorik ve deneysel bilgi birikimine sahip olmak
   3. Biyoteknoloji alanında akademik dünya ile iş dünyası arasında köprü olabilmek ve üniversite-sanayi işbirliklerinin kurulup geliştirilmesini sağlayabilmek

   Method of assessment

   1. Written exam
   2. Homework assignment
   3. Seminar/presentation
4. 4. Demonstrate an understanding of molecular dynamics, structure-based drug design and apply some of the techniques on a hands-on experience, creating a scientific report on the findings.

   Contribution to Program Outcomes

   1. Sanayinin Ar-Ge faaliyetleri için gerekli teorik ve deneysel bilgi birikimine sahip olmak
   2. Biyoteknoloji alanında akademik dünya ile iş dünyası arasında köprü olabilmek ve üniversite-sanayi işbirliklerinin kurulup geliştirilmesini sağlayabilmek

   Method of assessment

   1. Written exam
   2. Homework assignment
   3. Seminar/presentation
5. 5. Follow recent and new literature and be able to understand, interpret, and present the new data in a scientific manner in English.

   Contribution to Program Outcomes

   1. Doğru ve güvenilir bilgiye ulaşmanın yollarını bilmek
   2. Biyoteknoloji alanında hem Türkçe’yi hem de İngilizce’yi üst düzeyde kullanabilmek

   Method of assessment

   1. Written exam
   2. Homework assignment
   3. Seminar/presentation

Contents
Week 1:	Introduction to advanced biochemistry and intermolecular forces
Week 2:	Biomolecular structures and functions
Week 3:	Protein folding
Week 4:	Techniques to probe protein folding Homework 1
Week 5:	Cell membrane and membrane proteins
Week 6:	Molecular recognition and binding
Week 7:	Protein-protein interaction and allostery
Week 8:	Modulation of protein-protein interactions Midterm Exam
Week 9:	NMR spectroscopy and structure determination
Week 10:	Electron microscopy and structure determination
Week 11:	Enzymes as allosteric targets Homework 2
Week 12:	Molecular and protein dynamics
Week 13:	Structure-based drug design Computer-aided drug design workshop Homework 3
Week 14:	Presentations and bioinformatics tools demonstration
Week 15*:	Review on critical topics
Week 16*:	Final exam
Textbooks and materials:	The Molecules of Life Physical and chemical principles John Kuriyan, Boyana Konforti, David Wemmer Taylor and Francis
Recommended readings:	Proteins: Structures and molecular properties Thomas E. Creighton, W. H. Freeman Wiley
	* Between 15th and 16th weeks is there a free week for students to prepare for final exam.

Assessment
Method of assessment	Week number	Weight (%)
Mid-terms:	8	40
Other in-term studies:	0	0
Project:	0	0
Homework:	4, 11, 13	20
Quiz:	0	0
Final exam:	16	40
	Total weight:	(%)

Workload
Activity	Duration (Hours per week)	Total number of weeks	Total hours in term
Courses (Face-to-face teaching):	3	14
Own studies outside class:	5	14
Practice, Recitation:	1	3
Homework:	7	3
Term project:	0	0
Term project presentation:	0	0
Quiz:	0	0
Own study for mid-term exam:	8	2
Mid-term:	3	1
Personal studies for final exam:	10	3
Final exam:	3	1
		Total workload:
		Total ECTS credits:	*
	* ECTS credit is calculated by dividing total workload by 25. (1 ECTS = 25 work hours)