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Syllabus ( BTEC 542 )


   Basic information
Course title: Pharmaceutical Biotechnology and Drug Discovery
Course code: BTEC 542
Lecturer: Assoc. Prof. Dr. Mehmet ÖZBİL
ECTS credits: 7,5
GTU credits: 3 (3+0+0)
Year, Semester: 2020-2021, Fall
Level of course: Second Cycle (Master's)
Type of course: Area Elective
Language of instruction: Turkish
Mode of delivery: Face to face
Pre- and co-requisites: None
Professional practice: No
Purpose of the course: The aims of this course are to introduce students to pharmaceutical research, biotechnological tools for drug designing as well as some basic principles of drug design process, some of the key processes for novel and successful drug design.
   Learning outcomes Up

Upon successful completion of this course, students will be able to:

  1. 1. Understand and demonstrate the basic chemical and biological knowledge that sets the paving stone for pharmaceutical biotechnology and drug design.

    Contribution to Program Outcomes

    1. Biyoteknolojinin kapsamını, temellerini, uygulama alanlarını ve diğer bilim dallarıyla ilişkilerini kavramış olmak
    2. Başta biyoloji olmak üzere ilgili temel bilimlerde ve mühendislik alanlarında sağlam bir altyapıya sahip olmak

    Method of assessment

    1. Written exam
    2. Homework assignment
    3. Seminar/presentation
  2. 2. Demonstrate an understanding of the drug metabolism and mechanism of drug action that will help to design novel drug molecules.

    Contribution to Program Outcomes

    1. Türkiye’de ve dünyada biyoteknoloji sektörünü tanımak, sektörün ihtiyaçlarını, fırsatlarını ve sorunlarını bilmek
    2. Biyoteknoloji alanında girişimci olabilmek ve/veya yeni girişimlere gerek bilimsel ve teknik gerekse yönetsel katkı sağlayabilmek

    Method of assessment

    1. Written exam
    2. Homework assignment
  3. 3. Understand how proteins and enzymes work and develop understanding on their inhibition mechanisms, which is critical for both pharmaceutical and household industry.

    Contribution to Program Outcomes

    1. Biyoteknolojide sektörün ihtiyaçlarını giderebilecek ve sorunlarını çözebilecek yaklaşımlar geliştirebilmek ve Ar-Ge faaliyetleri yürütebilmek
    2. Biyoteknoloji alanında girişimci olabilmek ve/veya yeni girişimlere gerek bilimsel ve teknik gerekse yönetsel katkı sağlayabilmek

    Method of assessment

    1. Written exam
    2. Homework assignment
  4. 4. Demonstrate an understanding of computer aided drug design process, and apply some of the techniques on a hands-on experience, creating a scientific report on the findings.

    Contribution to Program Outcomes

    1. Tez konusu ile ilgili biyoteknoloji alanında (sağlık biyoteknolojisi, bitki biyoteknolojisi, endüstriyel biyoteknoloji veya sentetik ve sistem biyoteknolojisi) üst düzey ve güncel bilgilere sahip olmak
    2. Sanayinin Ar-Ge faaliyetleri için gerekli teorik ve deneysel bilgi birikimine sahip olmak
    3. Biyoteknoloji alanında akademik dünya ile iş dünyası arasında köprü olabilmek ve üniversite-sanayi işbirliklerinin kurulup geliştirilmesini sağlayabilmek

    Method of assessment

    1. Written exam
    2. Homework assignment
    3. Seminar/presentation
  5. 5. Follow recent and new literature and be able to understand, interpret, and present the new data in a scientific manner in English.

    Contribution to Program Outcomes

    1. Doğru ve güvenilir bilgiye ulaşmanın yollarını bilmek
    2. Biyoteknoloji alanında hem Türkçe’yi hem de İngilizce’yi üst düzeyde kullanabilmek

    Method of assessment

    1. Written exam
    2. Homework assignment
    3. Seminar/presentation
   Contents Up
Week 1: Introduction to medicinal chemistry
Week 2: Drug-receptor interactions, structure activity relationship
Week 3: Quantitative structure activity relationship
Week 4: Classification of drugs based on site and mode of action
Homework 1
Week 5: Pharmacokinetics/pharmacodynamics
Week 6: Protein Chemistry & Engineering-Structure
Week 7: Protein Chemistry & Engineering-Folding & Misfolding
Week 8: Regulation of protein folding
Mid-term exam
Week 9: Enzymology
Week 10: Gene engineering/recombinant DNA technology
Week 11: Rational drug design
Homework 2
Week 12: Introduction to computer-aided drug design
Week 13: Applications of computer-aided drug design
Computer-aided drug design workshop
Homework 3
Week 14: Presentations and discussions of computer-aided drug design workshop
Week 15*: Review on critical topics
Week 16*: Fınal exam
Textbooks and materials: Pharmaceutical Biotechnology
Drug Discovery and Clinical Applications
Second, Completely Revised, and Greatly Enlarged Edition
Eds.: Prof. Dr. Oliver Kayser & Prof. Dr. Heribert Warzecha
Wiley-Blackwell
Recommended readings: Fundamentals of Medicinal Chemistry
Gareth Thomas
Wiley
  * Between 15th and 16th weeks is there a free week for students to prepare for final exam.
Assessment Up
Method of assessment Week number Weight (%)
Mid-terms: 8 40
Other in-term studies: 0 0
Project: 0 0
Homework: 4, 11, 13 20
Quiz: 0 0
Final exam: 16 40
  Total weight:
(%)
   Workload Up
Activity Duration (Hours per week) Total number of weeks Total hours in term
Courses (Face-to-face teaching): 3 14
Own studies outside class: 5 14
Practice, Recitation: 1 3
Homework: 7 3
Term project: 0 0
Term project presentation: 0 0
Quiz: 0 0
Own study for mid-term exam: 8 2
Mid-term: 3 1
Personal studies for final exam: 10 3
Final exam: 3 1
    Total workload:
    Total ECTS credits:
*
  * ECTS credit is calculated by dividing total workload by 25.
(1 ECTS = 25 work hours)
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