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Syllabus ( BENG 312 )


   Basic information
Course title: Bioprocess Engineering Principles
Course code: BENG 312
Lecturer: Dr. Cansu ÜLKER TURAN
ECTS credits: 6
GTU credits: 3 ()
Year, Semester: 3, 6, Spring
Level of course: First Cycle (Undergraduate)
Type of course: Compulsory
Language of instruction: English
Mode of delivery: Face to face
Pre- and co-requisites: BENG211: Mass and Energy Balances
Professional practice: No
Purpose of the course: This course is intended to enable students to learn the basics of chemical reaction, bioreaction, and bioprocess engineering with different reactor types, including applications related to enzyme and microbial growth kinetics.
   Learning outcomes Up

Upon successful completion of this course, students will be able to:

  1. Solve biochemical reaction kinetics problems

    Contribution to Program Outcomes

    1. Acquire knowledge on biological, chemical, physical and mathematical principles which constitute the basis of bioengineering applications
    2. Understand design and production processes in bioengineering applications.
    3. Apply mathematical analysis and modeling methods for bioengineering design and production processes.

    Method of assessment

    1. Written exam
    2. Homework assignment
  2. Solve homogeneous and heterogeneous catalysis problems

    Contribution to Program Outcomes

    1. Acquire knowledge on biological, chemical, physical and mathematical principles which constitute the basis of bioengineering applications
    2. Understand design and production processes in bioengineering applications.
    3. Apply mathematical analysis and modeling methods for bioengineering design and production processes.

    Method of assessment

    1. Written exam
    2. Homework assignment
  3. Select and design bioreactors for bioengineering applications

    Contribution to Program Outcomes

    1. Understand design and production processes in bioengineering applications.
    2. Apply mathematical analysis and modeling methods for bioengineering design and production processes.

    Method of assessment

    1. Written exam
    2. Homework assignment
   Contents Up
Week 1: Introduction to bioprocess engineering, bioproducts and bioreactions
Week 2: Homogeneous reaction kinetics: basic concepts
Week 3: Reaction rate constants, factors affecting reaction rate
Week 4: Homogeneous reaction kinetics: sample problems and solutions
Homework I
Week 5: Introduction to enzyme kinetics: single enzyme/single substrate enzymatic reactions, Michaelis-Menten kinetics
Quiz I
Week 6: Enzyme inhibition: reversible and irreversible inhibition, allosteric inhibition
Week 7: Enzyme kinetics: sample problems and solutions
Homework II
Week 8: Midterm Exam
Week 9: Microbial growth kinetics: Monod kinetics and derivatives
Week 10: Microbial growth kinetics: Sample problem solutions
Quiz II
Week 11: Heterogeneous catalysis: enyzme and cell immobilization
Week 12: Heterogeneous catalysis: Problem solutions
Homework III
Week 13: Bioreactor engineering: batch, fed-batch, and continuous processes
Quiz III
Week 14: Bioreactor engineering: Sample problem solutions
Week 15*: -
Week 16*: Final Exam
Textbooks and materials: Octave Levenspiel, Chemical Reaction Engineering, 3rd Ed., 1998
Pauline Doran, Bioprocess Engineering Principles, 2nd Ed., 2013
Recommended readings: James E. Bailey, David. F. Ollis, Biochemical Engineering Fundamentals, 1986
James Shuler, Fikret Kargı, Matthew DeLisa, Bioprocess Engineering: Basic Concepts, 3rd Ed., 2017
John Villadsen, Jens Nielsen, Gunnar Liden, Bioreaction Engineering Principles, 3rd Ed., 2011
  * Between 15th and 16th weeks is there a free week for students to prepare for final exam.
Assessment Up
Method of assessment Week number Weight (%)
Mid-terms: 8 30
Other in-term studies: 0
Project: 0
Homework: 4, 7, 12 15
Quiz: 5, 10, 13 15
Final exam: 16 40
  Total weight:
(%)
   Workload Up
Activity Duration (Hours per week) Total number of weeks Total hours in term
Courses (Face-to-face teaching): 3 13
Own studies outside class: 4 14
Practice, Recitation: 0 0
Homework: 3 3
Term project: 0 0
Term project presentation: 0 0
Quiz: 1 3
Own study for mid-term exam: 3 7
Mid-term: 2 1
Personal studies for final exam: 3 7
Final exam: 2 1
    Total workload:
    Total ECTS credits:
*
  * ECTS credit is calculated by dividing total workload by 25.
(1 ECTS = 25 work hours)
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