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Syllabus ( BENG 461 )


   Basic information
Course title: Molecular Genetics
Course code: BENG 461
Lecturer: Assoc. Prof. Dr. Bengü ERGÜDEN
ECTS credits: 5
GTU credits: 3 ()
Year, Semester: 4, Spring
Level of course: First Cycle (Undergraduate)
Type of course: Area Elective
Language of instruction: English
Mode of delivery: Face to face
Pre- and co-requisites: BENG 223
Professional practice: No
Purpose of the course: To introduce the structure, organization and maintenance of the genome; principles and control of the gene expression.
   Learning outcomes Up

Upon successful completion of this course, students will be able to:

  1. explain the structure and organization of the genome, DNA and RNA

    Contribution to Program Outcomes

    1. Acquire knowledge on biological, chemical, physical and mathematical principles which constitute the basis of bioengineering applications
    2. Acquire knowledge on current bioengineering applications from the industrial and scientific aspects

    Method of assessment

    1. Written exam
  2. define the basic mechanisms of gene expression

    Contribution to Program Outcomes

    1. Acquire knowledge on biological, chemical, physical and mathematical principles which constitute the basis of bioengineering applications
    2. Acquire knowledge on current bioengineering applications from the industrial and scientific aspects

    Method of assessment

    1. Written exam
  3. explain how molecular genetic mechanisms are controlled and describe the techniques used for this process.

    Contribution to Program Outcomes

    1. Acquire knowledge on biological, chemical, physical and mathematical principles which constitute the basis of bioengineering applications
    2. Acquire knowledge on current bioengineering applications from the industrial and scientific aspects

    Method of assessment

    1. Written exam
   Contents Up
Week 1: Nucleic acids, DNA and RNA
Week 2: The structure of genome
Week 3: Nucleosomes and chromatin
Week 4: Quiz I
DNA replication
Week 5: DNA mutations and repair mechanisms
Week 6: Quiz II
Mechanism of transcription
Week 7: Transcriptional Regulation and Posttranscriptional Modifications
Week 8: Midterm Exam
DNA-protein interactions
Week 9: Translation
Week 10: Translational control
Week 11: The genetic code
Week 12: Quiz III
Epigenetics
Week 13: Techniques of Molecular Biology
Week 14: Quiz IV
Model organisms
Week 15*: -
Week 16*: Final Exam
Textbooks and materials: Molecular Biology of the Gene. James D. Watson, Tania A. Baker, Stephen P. Bell, Alexander Gann, Michael Levine, Richard Losick. 7th ed. 2013. Pearson.
Recommended readings: 1) Lewin’s Genes XII. Lewin, B. 9th ed. 2008. Jones and Bartlett Publishers.
2) Molecular Cell Biology. Harvey Lodish, Arnold Berk, Chris A. Kaiser, Monty Krieger, Matthew P. Scott, Anthony Bretscher, Hidde Ploegh, Paul Matsudaira. 8th Edition. Macmillan Learning.
  * Between 15th and 16th weeks is there a free week for students to prepare for final exam.
Assessment Up
Method of assessment Week number Weight (%)
Mid-terms: 8 30
Other in-term studies: 0
Project: 0
Homework: 0
Quiz: 5, 7, 12, 14 20
Final exam: 16 50
  Total weight:
(%)
   Workload Up
Activity Duration (Hours per week) Total number of weeks Total hours in term
Courses (Face-to-face teaching): 3 13
Own studies outside class: 4 14
Practice, Recitation: 0 0
Homework: 0 0
Term project: 0 0
Term project presentation: 0 0
Quiz: 1 4
Own study for mid-term exam: 10 1
Mid-term: 2 1
Personal studies for final exam: 15 1
Final exam: 2 1
    Total workload:
    Total ECTS credits:
*
  * ECTS credit is calculated by dividing total workload by 25.
(1 ECTS = 25 work hours)
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