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Syllabus ( BENG 520 )


   Basic information
Course title: Computational Neuroscience
Course code: BENG 520
Lecturer: Prof. Dr. Muhammet UZUNTARLA
ECTS credits: 7.5
GTU credits: 3 (3+0+0)
Year, Semester: 1/2, Fall
Level of course: Second Cycle (Master's)
Type of course: Area Elective
Language of instruction: English
Mode of delivery: Face to face
Pre- and co-requisites: None
Professional practice: No
Purpose of the course: The 100 billion nerve cells in the human brain support complex cognitive processes by gradually processing large amounts of information from the outside world. Each stage in the highly advanced visual perception process is a computational unit that extracts visual features for object identification from images falling on the retina. Therefore, localizing the different stages of the visual cortex in the brain and determining the types of information processed at each stage are among the most important neuroscience problems of our time.
We develop innovative functional magnetic resonance imaging (fMRI) and machine learning techniques to answer these important questions. With the unique technology we have developed, the neural responses that occur during natural vision, hearing, and language perception can be detected with unprecedented sensitivity. In addition to the detailed examination of the structure and function of the brain's subsystems, these techniques also make it possible to read the brain - to analyze the content of perception back from brain activity.
An exemplary field of application is the extraction and mapping of mathematical models of the visual cortex in the human brain. Although real-world scenes are mixed with many different objects, humans are extremely adept at finding target objects in natural settings and quickly switching their attention between different targets. The precise neural mechanisms mediating this extraordinary ability are not yet known. Previous studies have reported relatively simple mechanisms that improve the quality of brain activity evoked by the objects involved, without affecting the way information is represented in each brain region. However, as there are a limited number of cortical neurons, it seems highly unlikely that all brain regions hold stable representations regardless of behavioral demands.
To examine the nature of neural representations during image search, we develop a powerful computational modeling technique to describe complex natural movies and the relationship between visual information and brain activity. We analyze the correlations between high-dimensional imaging data and high-dimensional visual stimuli at the same level with advanced machine learning techniques.
This course aims to evaluate the mathematical models and statistical analysis methods required for the encryption and decoding of neural information.

   Learning outcomes Up

Upon successful completion of this course, students will be able to:

  1. Use the terminology associated with the anatomy, physiology and functional organizations of the neural systems

    Contribution to Program Outcomes

    1. Develop their knowledge in the fields of Bioengineering and Biotechnology at the level of expertise based on undergraduate qualifications.

    Method of assessment

    1. Written exam
  2. Model the electrical behaviors of neurons at the cellular level and population level through computational approaches

    Contribution to Program Outcomes

    1. Define, model and solve engineering problems in the field of bioengineering at a higher level.
    2. Use up-to-date techniques and computational tools for advanced engineering applications.
    3. Solve problems that require expertise in the field of bioengineering by using scientific research methods.

    Method of assessment

    1. Written exam
  3. Explain the concept of synaptic plasticity and the neurophysiology of cognitive brain functions

    Contribution to Program Outcomes

    1. Develop their knowledge in the fields of Bioengineering and Biotechnology at the level of expertise based on undergraduate qualifications.
    2. Construct an experiment for a problem in the field of Bioengineering and Biotechnology, develop a solution method, solve it, evaluate the results and to have synthesis skills.
    3. Have investigative, productive and entrepreneurial capacity by using high-level mental processes such as creative and critical thinking, taking initiative and decision making.

    Method of assessment

    1. Written exam
   Contents Up
Week 1: Traditional neuroscience and computational neuroscience
Week 2: Current problems investigated by neuroscience
Week 3: Anatomy and physiology of neurons and synapses
Week 4: Anatomical and functional organization of the brain
Week 5: Electrical properties of neurons, action potential, ion channels
Project assignments
Week 6: Mathematical modeling
Midterm exam
Week 7: Mathematical models of neurons and synapses
Week 8: Complex neural networks, population modeling
Week 9: Neuronal noise
Week 10: Biological neural networks
Week 11: Short- and long-term synaptic plasticity
Week 12: Synaptic plasticity in the pathological case
Week 13: Synaptic plasticity and learning
Week 14: Synaptic plasticity and memory
Project presentations
Week 15*: -
Week 16*: Final exam
Textbooks and materials: Peter Dayan and L.F. Abbott, "Theoretical neuroscience: Computational and mathematical modeling of neural systems", MIT Press, Cambridge, 2001.

William W. Lytton, "From computer to brain: foundations of computational neuroscience", 2002.
Recommended readings: Bruce Katz, "Neuroengineering the future", Infinity Science Press, Ingham, 2008.

Eugene M. Izhikevich, "Dynamical systems in neuroscience: The geometry of excitability and bursting", MIT Press, Cambridge, 2007.

Eric R. Kandel, John D. Koester, Sarah H. Mack, Steven A. Siegelbaum, "Principles of neural science", McGraw-Hill, New York, 2012.
  * Between 15th and 16th weeks is there a free week for students to prepare for final exam.
Assessment Up
Method of assessment Week number Weight (%)
Mid-terms: 6 30
Other in-term studies: - 0
Project: 5-14 20
Homework: - 0
Quiz: - 0
Final exam: 16 50
  Total weight:
(%)
   Workload Up
Activity Duration (Hours per week) Total number of weeks Total hours in term
Courses (Face-to-face teaching): 3 14
Own studies outside class: 5 14
Practice, Recitation: 0 0
Homework: 0 0
Term project: 6 10
Term project presentation: 1 1
Quiz: 0 0
Own study for mid-term exam: 5 1
Mid-term: 2 1
Personal studies for final exam: 5 1
Final exam: 2 1
    Total workload:
    Total ECTS credits:
*
  * ECTS credit is calculated by dividing total workload by 25.
(1 ECTS = 25 work hours)
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