• Basic information
• Learning outcomes
• Contents
• Assessment
• Workload

Learning outcomes

Upon successful completion of this course, students will be able to:

1. Basic principles and scope toxicology, Mechanisms and interactions of toxicants.

   Contribution to Program Outcomes

   1. Define, Chemical, Biological, Radiological and Nuclear (cbrn) concepts in a specialized way and apply them in CBRN defense
   2. Understand relevant research methodologies and techniques and their appropriate application within his/her research field
   3. Analyze critically and evaluate his/her findings and those of others
   4. Summarize, document, report and reflect on progress
   5. Write progress reports clearly on the basis of published documents, thesis, etc
   6. Question and find out innovative approaches
   7. Work effectively in multi-disciplinary research teams
   8. Asses risks of natura lor human made CBRN threats
   9. Develop an awareness of continuous learning in relation with modern technology
   10. Find out new methods to improve his/her knowledge
   11. Effectively express his/her research ideas and findings both orally and in writing
   12. Support his/her ideas with various arguments and present them clearly to a range of audience, formally and informally through a variety of techniques
   13. Be aware of issues relating to the rights of other researchers and of research subjects e.g. confidentiality, attribution, copyright, ethics, malpractice, ownership of data
   14. Apply of chemical, biological, radiological and nuclear concepts to individual, social, economic, technological and ethical aspects

   Method of assessment

   1. Written exam
   2. Homework assignment
2. Analyzing and evaluation of toxicity by in situ, in vitro and in vivo methods.

   Contribution to Program Outcomes

   1. Define, Chemical, Biological, Radiological and Nuclear (cbrn) concepts in a specialized way and apply them in CBRN defense
   2. Understand relevant research methodologies and techniques and their appropriate application within his/her research field
   3. Analyze critically and evaluate his/her findings and those of others
   4. Summarize, document, report and reflect on progress
   5. Work effectively in multi-disciplinary research teams
   6. Asses risks of natura lor human made CBRN threats
   7. Develop an awareness of continuous learning in relation with modern technology
   8. Find out new methods to improve his/her knowledge
   9. Effectively express his/her research ideas and findings both orally and in writing
   10. Support his/her ideas with various arguments and present them clearly to a range of audience, formally and informally through a variety of techniques
   11. Be aware of issues relating to the rights of other researchers and of research subjects e.g. confidentiality, attribution, copyright, ethics, malpractice, ownership of data
   12. Understand relevant health and safety issues and demonstrate responsible working practices
   13. Apply of chemical, biological, radiological and nuclear concepts to individual, social, economic, technological and ethical aspects

   Method of assessment

   1. Written exam
   2. Homework assignment
3. Understanding toxic chemical and biological agents and their mechanisms

   Contribution to Program Outcomes

   1. Define, Chemical, Biological, Radiological and Nuclear (cbrn) concepts in a specialized way and apply them in CBRN defense
   2. Understand relevant research methodologies and techniques and their appropriate application within his/her research field
   3. Analyze critically and evaluate his/her findings and those of others
   4. Work effectively in multi-disciplinary research teams
   5. Develop stragies and/or product in order decicease risks of national and intenational CBRN threats
   6. Find out new methods to improve his/her knowledge
   7. Effectively express his/her research ideas and findings both orally and in writing
   8. Be aware of issues relating to the rights of other researchers and of research subjects e.g. confidentiality, attribution, copyright, ethics, malpractice, ownership of data
   9. Apply of chemical, biological, radiological and nuclear concepts to individual, social, economic, technological and ethical aspects

   Method of assessment

   1. Written exam
   2. Homework assignment

Contents
Week 1:	Basic Principles and Scope Toxicology
Week 2:	Cellülar and Molecular Mechanisms of Toxicity
Week 3:	Chemical and Biological Factors Effecting Toxicity
Week 4:	Absorption, Distribution and Excreation of Toxicants
Week 5:	Organ Toxicity
Week 6:	Toxicity Mechanisms of Chemical and Biological Agents
Week 7:	Pharmacotoxicology
Week 8:	Midterm Exam
Week 9:	Ecotoxicology
Week 10:	Nanotoxicology
Week 11:	Analytic Toxicology
Week 12:	Toxicity Testing and Alternative Methods
Week 13:	Exposure Assessment and Risk Characterization
Week 14:	Poisoning mechanisms, diagnosis and treatments of toxicants
Week 15*:	Seminar, Presentation
Week 16*:	FinalExam
Textbooks and materials:	Casarett & Doull's Toxicology: The Basic Science of Poisons, 7th Edition, 2008. Curtis D. Klaassen A Textbook of Modern Toxicology, 4th Edition, 2010. Ernest Hodgson, John Wiley & Sons, Inc., Hoboken, New Jersey Molecular & Biochemical Toxicology – 4th edition, 2008. Smart. John Wiley & Sons, Inc., Hoboken, New Jersey
Recommended readings:	Toksikoloj i, Nevin Vural Zehirlenmeler, Selim Kurtoğlu Goldfrank’s Toxicologic Emergencies, L.R. Goldfrank, N.E. Flomenbaum, N.E. Lewin, R.S. Weisman, M.A. Howland, R.S. Hoffman. European Medical Agency, ICH Standarts * Between 15th and 16th weeks is there a free week for students to prepare for final exam.
	* Between 15th and 16th weeks is there a free week for students to prepare for final exam.

Assessment
Method of assessment	Week number	Weight (%)
Mid-terms:	8	40
Other in-term studies:		0
Project:	15,16	5
Homework:	4	5
Quiz:	2,4,6,10,12,14	10
Final exam:	16	40
	Total weight:	(%)

Workload
Activity	Duration (Hours per week)	Total number of weeks	Total hours in term
Courses (Face-to-face teaching):	4	16
Own studies outside class:	11	4
Practice, Recitation:	2	10
Homework:	1	2
Term project:	1	10
Term project presentation:	1	4
Quiz:	1	16
Own study for mid-term exam:	1	10
Mid-term:	2	1
Personal studies for final exam:	2	5
Final exam:	2	1
		Total workload:
		Total ECTS credits:	*
	* ECTS credit is calculated by dividing total workload by 25. (1 ECTS = 25 work hours)