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İçerik
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| 1. hafta: |
Protein function general overview (Pymol) |
| 2. hafta: |
Noncovalent interactions between atoms in biomolecules (PyMol) |
| 3. hafta: |
Hierarchy in protein structure, Primary structure, Amino acids ( Chemical and physical properties). |
| 4. hafta: |
Hierarchy in protein structure, Secondary structure (PyMol) |
| 5. hafta: |
Hierarchy in protein structure, Tertiary and quaternary structures (PyMol) |
| 6. hafta: |
post-translational modifications and metal centers (PyMol)
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| 7. hafta: |
Vize sınavı
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| 8. hafta: |
energetics and protein stability, CD, flouresence, Thermal melting, spectroscopy ( Spartan) |
| 9. hafta: |
Protein-Ligand Interactions (Docking) |
| 10. hafta: |
Methods of Structure Determination x-ray, nmr, epr and hdx-ms (Docking) |
| 11. hafta: |
The structure of the Membrane proteins, channels and transporters (Docking) |
| 12. hafta: |
The structure of the Membrane proteins, channels and transporters (Docking) |
| 13. hafta: |
Protein structure and a molecular approach to medicine (Docking) |
| 14. hafta: |
Protein structure and a molecular approach to medicine (Docking) |
| 15. hafta*: |
Genel Değerlendirme |
| 16. hafta*: |
Final sınavı |
| Ders kitapları ve materyaller: |
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| Önerilen kaynaklar: |
1. Protein Structure and Fuction, Petsko G, A and Ringe D;
2. Introduction to protein structure, Branden C;
3. Introduction to Protein Architecture, Lesk A, M;
4. Lehninger Principles of Biochemistry,David L. Nelson, Michael M. Cox
5. http://structome.org/index.php/Main_Page http://spdbv.vital-it.ch/
http://dock.compbio.ucsf.edu/DOCK_6/index.htm |
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* 15. ve 16. haftalar arası final sınavına hazırlık haftası bulunmaktadır.
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