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Syllabus ( MBG 439 )


   Basic information
Course title: Neurobiology
Course code: MBG 439
Lecturer: Prof. Dr. Işıl KURNAZ
ECTS credits: 5
GTU credits: 3 (3+0+0)
Year, Semester: 2024, Fall
Level of course: First Cycle (Undergraduate)
Type of course: Area Elective
Language of instruction: English
Mode of delivery: Face to face
Pre- and co-requisites: none
Professional practice: No
Purpose of the course: The aim of the course is to give students basic knowledge on the structure and functions of nervous system. In this context, the development of nervous system, its cellular and molecular architecture will first be defined. Then, the generation of neural impulses, their transmission through synapses and different levels of regulation of the synaptic transmission will be discussed. Cellular aspects of learning and memory will also be considered. Finally, the course will deal with diseases affecting the nervous system such as neurodegenerative, psychological and language disorders.
   Learning outcomes Up

Upon successful completion of this course, students will be able to:

  1. Describe the structural and functional organisation of nervous system.

    Contribution to Program Outcomes

    1. To be able to define general concepts and problems related to Molecular Biology and Genetics and to produce solutions.
    2. To be able to define the structure-function relationship at the molecular level in cells and organisms.

    Method of assessment

    1. Written exam
    2. Oral exam
  2. Explain the generation of action potential and transmisson of neural impulses.

    Contribution to Program Outcomes

    1. To be able to define general concepts and problems related to Molecular Biology and Genetics and to produce solutions.
    2. To be able to define the structure-function relationship at the molecular level in cells and organisms.

    Method of assessment

    1. Written exam
    2. Oral exam
  3. Describe cellular aspects of learning and memory

    Contribution to Program Outcomes

    1. To be able to define general concepts and problems related to Molecular Biology and Genetics and to produce solutions.
    2. To be able to define the structure-function relationship at the molecular level in cells and organisms.
    3. To be able to explain the genetic information flow in organisms and populations.
    4. To be able to apply biological concepts to individual, social, economic, technologic and environmental issues and to develop sustainable approaches for problem solving.

    Method of assessment

    1. Written exam
    2. Oral exam
  4. Distinguish molecular mechanisms of neurodegenerative, psychological and language disorders.

    Contribution to Program Outcomes

    1. To be able to define general concepts and problems related to Molecular Biology and Genetics and to produce solutions.
    2. To be able to define the structure-function relationship at the molecular level in cells and organisms.
    3. To be able to explain the genetic information flow in organisms and populations.
    4. To be able to apply biological concepts to individual, social, economic, technologic and environmental issues and to develop sustainable approaches for problem solving.

    Method of assessment

    1. Written exam
    2. Oral exam
  5. The students are expected to obtain a basic knowledge of the nervous system and its cells, namely neurons and glia, and to identify structure-function relationships in neurons. They will gain basic knowledge of fundamentals of neuroscience, how neurons function, and how they develop in the embryo, as well as a brief understanding of neurological diseases, as well as molecular mechanisms of learning and memory.

    Contribution to Program Outcomes

    1. To be able to define general concepts and problems related to Molecular Biology and Genetics and to produce solutions.
    2. To be able to define the structure-function relationship at the molecular level in cells and organisms.
    3. To be able to comprehend the history and nature of scientific thinking and to apply them to problems in the field.
    4. To be able to follow current scientific and technological innovations with the awareness of continuous learning and to apply them in the field.
    5. To be able to apply biological concepts to individual, social, economic, technologic and environmental issues and to develop sustainable approaches for problem solving.

    Method of assessment

    1. Written exam
    2. Homework assignment
  6. Students are expected to obtain basic knowledge of the nervous system and structure-function relationships between its cellular units, mainly neurons and glia

    Contribution to Program Outcomes

    1. To be able to define the structure-function relationship at the molecular level in cells and organisms.
    2. To be able to comprehend the history and nature of scientific thinking and to apply them to problems in the field.
    3. To be able to follow current scientific and technological innovations with the awareness of continuous learning and to apply them in the field.
    4. To be able to apply biological concepts to individual, social, economic, technologic and environmental issues and to develop sustainable approaches for problem solving.

    Method of assessment

    1. Written exam
    2. Homework assignment
  7. The students are expected to have a general knowledge of the nervous system and its cellular components; they will learn about the structure-function relationships, and gain a fundamental understanding of common neurological disorders.

    Contribution to Program Outcomes

    1. To be able to define the structure-function relationship at the molecular level in cells and organisms.
    2. To be able to comprehend the history and nature of scientific thinking and to apply them to problems in the field.
    3. To be able to follow current scientific and technological innovations with the awareness of continuous learning and to apply them in the field.
    4. To be able to apply biological concepts to individual, social, economic, technologic and environmental issues and to develop sustainable approaches for problem solving.

    Method of assessment

    1. Written exam
    2. Homework assignment
   Contents Up
Week 1: Introduction to neurons and behavior
Week 2: Neurocytoskeleton 1; molecules and structures
Week 3: Neurocytoskeleton 2; protein synthesis in neurons; axonal transport
Week 4: Ion channels, Membrane potential; action potential
Week 5: Synaptic transmission
Week 6: Modulation of synaptic transmission;Synaptic integration
Midterm Exam
Week 7: Neuroanatomy – Functional organization of the nervous system
Week 8: Development of the nervous system 1; embyronic neurogenesis, neuronal identitiy and lineage specification şn CNS and PNS, signaling and transcriptional control
Week 9: Development of the nervous system 2; axon guidance, target identification, synapse formation and pruning
Week 10: Learning and memory
Week 11: Cellular aspects of learning and memory
Week 12: Aging in the brain; Neurodegenerative disorders
Week 13: Language and learning disorders 1; psychological disorders
Week 14: Language and learning disorders 2; neurological drugs; connectomics; optogenetics
Week 15*: -
Week 16*: Final Exam
Textbooks and materials: Principles of Neural Science, Kandel, Schwartz, Jessell, McGraw Hill, 2000, 4th Ed.

Recommended readings: From Neuron to Brain, Nicholls, Martin, Wallace, Fuchs
  * Between 15th and 16th weeks is there a free week for students to prepare for final exam.
Assessment Up
Method of assessment Week number Weight (%)
Mid-terms: 7 35
Other in-term studies: 0
Project: 0
Homework: 0
Quiz: 3, 4, 5, 9, 11, 12 15
Final exam: 16 50
  Total weight:
(%)
   Workload Up
Activity Duration (Hours per week) Total number of weeks Total hours in term
Courses (Face-to-face teaching): 3 14
Own studies outside class: 4 14
Practice, Recitation: 0 0
Homework: 0 0
Term project: 0 0
Term project presentation: 0 0
Quiz: 2 6
Own study for mid-term exam: 8 1
Mid-term: 0 0
Personal studies for final exam: 0 0
Final exam: 12 1
    Total workload:
    Total ECTS credits:
*
  * ECTS credit is calculated by dividing total workload by 25.
(1 ECTS = 25 work hours)
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