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Contents
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| Week 1: |
Screening for new metabolites from marine microorganisms.
DNA sequencing data from marine microorganisms, completed and uncompleted sequencing projects.
Examples of metabolites from marine microorganisms. Application of proteomics for analysis of targeted antibacterial compounds.
Fatty acids from lipids of marine organisms:
Molecular biodiversity, rules as biomarkers, biologically active compounds, and economical aspects.
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| Week 2: |
Fish and shellfish upgrading, traceability: Hydrolysates and last developments.
Marine microalgae: Metabolic engineering and production of useful chemicals from microalgae. Gene analysis of microalgae. Microalgal culture techniques.
Marine enzymes: Extremophyles and symbiotic marine microorganisms. Microorganisms from marine water and sediments. Molecular methods for identifying biological diversity.
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| Week 3: |
New biocatalysts and extreme environments as a resource for microorganisms. Microorganisms adapted to low and high temperatures, microorganisms living in extremely acidic environments, microorganisms tolerating extremely salted environments. |
| Week 4: |
Aquaculture of “non-food” organisms. |
| Week 5: |
Antifouling technologies. |
| Week 6: |
Downstream processing in marine biotechnology.
Data from biological processes for culturing of marine yeast and prokaryotes.
Bioprocess engineering data from marine mesophylic bacteria and yeast.
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| Week 7: |
Bioprocess engineering data from marine hyperthermophylic and barophylic Archaea.
Bioprocess engineering data.
General bioprocessing technologies.
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| Week 8: |
Midterm Exam |
| Week 9: |
Purification and isolation of enzymes. Processing of oligo and polysaccharides.
Isolation and purification of chitin and chitinosan. Isolation of fucoidan and fucoidanoses.
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| Week 10: |
Processing of unsaturated fatty acids. Processing of low molecular weight bioactive compounds. |
| Week 11: |
Marine pharmacology: potentialities in the treatment of infectious diseases, osteoporosis and Alzheimer’s disease.
Marine originated anti-tuberclosis agents. New anti-malarian agents originated from natural marine products. Zoantamin family as a potential anti-osteoporosis. Promising agent to treat Alzheimer’s disease.
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| Week 12: |
Asymmetric total synthesis of complex marine natural products. Examples from selected synthesis. |
| Week 13: |
Seafood allergy: lessons from clinical symptoms, immunological mechanisms and molecular biology. Applications and future steps. |
| Week 14: |
Reproductive biotechnology of shellfish and fin fishes. Transgenic animals. Methods in gene transfers. Production of transgenic fishes. Gene transfers in shellfish and fin fish. Development of fish strains. Transgenic fish models for identifying of environmental xenobiotics |
| Week 15*: |
Ethics and future aspects of aquatic biotechnology. |
| Week 16*: |
Final exam |
| Textbooks and materials: |
Marine Biotechnology handouts |
| Recommended readings: |
1. Marine Biotechnology I. Advances in Biochemical Engineering /Biotechnology 96. Springer. Volume editors: Y. Le Gal and R. Ulber
2. Marine Biotechnology II. Advances in Biochemical Engineering /Biotechnology 97. Springer. Volume editors: Y. Le Gal and R. Ulber.
3. Biotechnology of Aquatic Animals. Editors: R. Nagabhushanam, A.D. Diwan, B.J. Zahuranec, R. Sarojini.
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* Between 15th and 16th weeks is there a free week for students to prepare for final exam.
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