• Basic information
• Learning outcomes
• Contents
• Assessment
• Workload

Learning outcomes

Upon successful completion of this course, students will be able to:

1. Gain knowledge about The Human Microbiota and Microbiomes

   Contribution to Program Outcomes

   1. Define and manipulate advanced concepts of Biology
   2. Critically review the literature pertaining to his/her research projects, and connect the earlier literature to his/her own results,
   3. Define the relationship among life forms and their environments and ecosystems
   4. Identify structure-function relationships in cells and organisms
   5. Know and apply the techniques used in gene and protein engineering / microbial identification / enzyme technologies / mammalian cell culture and plant tissue culture manipulations.
   6. Ability to work independently and take responsibility
   7. Acquire scientific knowledge and work independently,
   8. Find out new methods to improve his/her knowledge.
   9. Effectively express his/her research ideas and findings both orally and in writing
   10. Demonstrate professional and ethical responsibility.
   11. Apply biological concepts to personal, social, economical, technological and ethical issues

   Method of assessment

   1. Written exam
   2. Homework assignment
   3. Seminar/presentation
   4. Term paper
2. Gain knowledge about microorganisms (such as, Archaeae, bacteria and viruses) reside the Human Microbiota, disease and their identification.

   Contribution to Program Outcomes

   1. Define and manipulate advanced concepts of Biology
   2. Define the relationship among life forms and their environments and ecosystems
   3. Explain transmission of genetic background in organisms and populations
   4. Acquire scientific knowledge and work independently,
   5. Find out new methods to improve his/her knowledge.
   6. Effectively express his/her research ideas and findings both orally and in writing
   7. Apply biological concepts to personal, social, economical, technological and ethical issues

   Method of assessment

   1. Written exam
   2. Term paper
3. Gain knowledge about the human microbiome projects

   Contribution to Program Outcomes

   1. Define and manipulate advanced concepts of Biology
   2. Identify structure-function relationships in cells and organisms
   3. Know and apply the techniques used in gene and protein engineering / microbial identification / enzyme technologies / mammalian cell culture and plant tissue culture manipulations.
   4. Acquire scientific knowledge and work independently,
   5. Find out new methods to improve his/her knowledge.
   6. Effectively express his/her research ideas and findings both orally and in writing
   7. Apply biological concepts to personal, social, economical, technological and ethical issues

   Method of assessment

   1. Written exam
   2. Homework assignment

Contents
Week 1:	What are the human microbiomes and microbiotas? Physiological and anatomical structure of the human microbiota
Week 2:	The human microbiome projects and updated data
Week 3:	Bacterial microbiomes: Firmicutes, Bacteroidetes, Proteobacteria, Verrumicrobia, Actinobacteria, Fusobacteria, Cyanobacteria, Actinomyces viscosus, A. Naeslundii, Lactobacillus sp. Lactobacillus acidophilus, L. iners, L. crispatus. L. jensenii, L. delbruekii, L. gasseri. Staphylococci.
Week 4:	Archaea: Methanobrevibacter smithii, Methanosphaera stadtmanae
Week 5:	Fungi: Candida sp., Malassezia sp
Week 6:	Viruses: Diversity of human viruses Bacterial viruses (bacteriophages) Human immunodeficiency virus: HIV Human virome and related studies Human papillomavirus
Week 7:	Inflammatory bowel disease: ulcerative colitis and Crohn’s disease
Week 8:	MIDTERM EXAM
Week 9:	The human microbiota and cancer types: Colorectal cancer. Gastric cancer. Esophageal cancer.
Week 10:	Infection with Clostridium difficile. Infection with Helicobacter pylori.
Week 11:	Bacterial vaginosis Infection with HIV
Week 12:	The human microbiota associated with gastrointestinal malignancy
Week 13:	The human microbiota and liver diseases The human microbiota and metabolic disorders: Obesity, Type 2 diabetes
Week 14:	The human microbiota and other diseases: The microbiota and allergic diseases, The microbiota and psychiatric diseases
Week 15*:	REPRESENTATION OF STUDENT PROJECTS
Week 16*:	FINAL EXAM
Textbooks and materials:	Ders notları Her haftanın konusu ile ilgili güncel makaleler
Recommended readings:	1.The Human Microbiota and Microbiome, Julian R Marchesi , 14 Mayıs 2014, CABI 2. The Human Microbiome Handbook. Jason Tetro, Emma Allen-Vercoe DEStech Publications, Inc, 15 Mar 2016 - 370 sayfa 3. The Human Microbiome, An Issue of Clinics in Laboratory Medicine, E-Book. Matthew R. Pincus , 12 Kasım 2014 , Elsevier Health Sciences 4. The Human Microbiome: The Germs That Keep You Healthy. Rebecca E. Hirsch 1 Ağustos 2016. Twenty-First Century Books 5. The Human Microbiome. Colin Harwood 17 Kasım 2017. Academic Press 6. The Human Microbiome: Ethical, Legal and Social Concerns. Rosamond Rhodes, Nada Gligorov, Abraham Paul Schwab. Oxford University Press, 15 Ağu 2013 - 288 sayfa 7. Welcome to the Microbiome: Getting to Know the Trillions of Bacteria and Other Microbes In, On, and Around You. Rob DeSalle Susan L. Perkins . 10 Kasım 2015 8. Human Microbiome and Dysbiosis in Clinical Disease: Volume 1: Parts 1 - 4, 2. cilt Alex Vasquez. International College of Human Nutrition & Functional Medicine, 23 May 2015
	* Between 15th and 16th weeks is there a free week for students to prepare for final exam.

Assessment
Method of assessment	Week number	Weight (%)
Mid-terms:	8	20
Other in-term studies:		0
Project:	15	10
Homework:	4, 5, 6, 9, 10, 12	30
Quiz:		0
Final exam:	16	40
	Total weight:	(%)

Workload
Activity	Duration (Hours per week)	Total number of weeks	Total hours in term
Courses (Face-to-face teaching):	3	14
Own studies outside class:	3	14
Practice, Recitation:	0	0
Homework:	6	14
Term project:	3	1
Term project presentation:	1	1
Quiz:	0	0
Own study for mid-term exam:	3	1
Mid-term:	3	1
Personal studies for final exam:	3	1
Final exam:	1	1
		Total workload:
		Total ECTS credits:	*
	* ECTS credit is calculated by dividing total workload by 25. (1 ECTS = 25 work hours)