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Contents
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| Week 1: |
Viral genetics and gene therapies: definitions, classification, morphology and chemistry: An introduction to viruses, their nature, structure and classification |
| Week 2: |
Virus replicatıon strategies :Principal events involved in replication: Adsorption, penetration, uncoating nucleic acid and protein synthesis, assembly, maturation and release. Replicative strategies employed by animal DNA viruses. Identification of virus prototypes associated with different DNA virus replication schemes
Replicative strategies employed by animal RNA viruses. Identification of virus prototypes associated with different RNA virus replication schemes |
| Week 3: |
Introduction to animal virus genetics
Viruses that cause cancer and the mechanisms by which they do so: DNA cancer viruses (polyoma, herpes, papilloma, hepatitis, adenovirus). RNA cancer viruses (retroviruses)
HUMAN IMMUNODEFICIENCY VIRUS: The biology of the virus that causes AIDS
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| Week 4: |
History of vaccines especially smallpox and polio. New methods: subunit vaccines, anti-idiotype and DNA vaccines
Viral chemotherapy: Drugs that have been used against viruses: Nucleoside analogs, reverse transcriptase inhibitors, protease inhibitors |
| Week 5: |
Picornaviruses: Enteroviruses, rhinoviruses: Picornaviruses: Small RNA viruses that cause infections of the alimentary tract including polio (enteroviruses) and of the upper respiratory tract (rhinoviruses) |
| Week 6: |
Reolication of polio and another picornaviruses |
| Week 7: |
The structure of herpes viruses. The diseases caused by herpes simplex types 1 and 2, cytomegalovirus, varicella-zoster virus, Epstein-Barr virus and other herpes types. |
| Week 8: |
Midterm exam I |
| Week 9: |
Host specific and nonspecific defense mechanisms involved in resistance to and recovery from virus infections. Role of interferon in viral infections. Mechanisms by which interferon exerts its antiviral activity. Contributions of various host defense mechanisms in viral infections |
| Week 10: |
Influenza virus structure and properties. Viral pathogenesis and disease, genetics, epidemiology, prevention and treatment |
| Week 11: |
Structure and properties of measles and mumps viruses. Viral pathogenesis and disease, epidemiology, prevention and treatment. Structure and properties of rubella virus. German Measles pathogenesis and disease, epidemiology, prevention and treatment.
Parainfluenza, respiratory syncytial and adenovirus: Viruses that cause respiratory disease |
| Week 12: |
Rotaviruses and other agents of viral gastroenteritis: Viruses that cause alimentary tract infections.
Hepatitis viruses : The structure and replication of hepatitis A to E
Hepatitis A and E (Infectious and enteric non-A, non- B): The diseases that are caused by the hepatitis viruses
Hepatitis B, C, D and G (Serum hepatitis, non A, non-B hepatitis and Delta Antigen)
Rabies Rhabdoviruses and the disease of rabies.
Arboviruses: Arbovirus encephalitis, febrile and hemorrhagic disease. Rodent borne hemorrhagic fever, hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. Other filovirus-associated hemorrhagic fevers
Viral diseases transmitted by Vertebrates: Convansional and Unconvensial agents (Slow viral diseases) : Slow viral diseases of the central nervous system. Progressive multifocal leukoencephalopathy.Sub-acute sclerosing panencephalitis (measles virus). Prion diseases: Kuru, Creutzfeld-Jakob disease |
| Week 13: |
CORONAVIRUSES - COLDS AND SARS: The viruses that cause about one third of common colds and the newly described severe acute respiratory syndrome
Parvoviruses and Fifth disease: Childhood rash disease |
| Week 14: |
Structure of bacteriophage. The infectious process and the lytic multiplication cycle. The lysogenic cycle and its regulation. Midterm exam II |
| Week 15*: |
Plant Viruses |
| Week 16*: |
Final exam |
| Textbooks and materials: |
Ders notları
Course handouts |
| Recommended readings: |
1. Recent Advances in Plant Virology. Publisher: Caister Academic Press Editors: Carole Caranta1, Miguel A. Aranda2, Mark Tepfer3 and J.J. Lopez-Moya4 Publication date: February 2011
ISBN: 978-1-904455-75-2
2. Animal Viruses: Molecular Biology. Publisher: Caister Academic Press
Editor: Thomas C. Mettenleiter and Francisco Sobrino Friedrich-Loeffler-Institut, Publication date: January 2008 ISBN: 978-1-904455-22-6
3. Principles of Molecular Virology (Standard Edition), Third Edition [Hardcover] . Alan J. Cann (Author). Academic Press.
4. Non-viral Gene Therapy: Gene Design and Delivery by Kazunari Taira, Kazunori Kataoka and Takuro Niidome (13 Jun 2005)
5. Gene Therapy by Mauro Giacca (22 Apr 2010)
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* Between 15th and 16th weeks is there a free week for students to prepare for final exam.
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