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Syllabus ( MBG 630 )

   Basic information
Course title: Molecular And Cellular Immunology
Course code: MBG 630
Lecturer: Prof. Dr. Tamer YAĞCI
ECTS credits: 7.5
GTU credits: 3 (3+0+0)
Year, Semester: 1/2, Fall and Spring
Level of course: Second Cycle (Master's)
Type of course: Area Elective
Language of instruction: English
Mode of delivery: Face to face
Pre- and co-requisites: none
Professional practice: No
Purpose of the course: TTo lead students to gain below outcomes;
1: will have information about the tissues and cells of the immune system,
2: know mechanisms of the innate and adaptive immunity,
3: have knowledge about integration of the cellular and humoral immunities against pathogens that invade our organisms, molecular bases of the antigen processing and antigen presentation to the immune system.
4: This basic knowledge will allow students to better understand topics such as diseases of the immune system, transplantation, allergy and tumor immunology.
   Learning outcomes Up

Upon successful completion of this course, students will be able to:

  1. Describe molecular mechanisms that mediate the activation of innate and adaptive immune systems.

    Contribution to Program Outcomes

    1. Define and manipulate advanced concepts of Biology

    Method of assessment

    1. Written exam
  2. Distinguish between different types of immune responses depending on the nature of antigen.

    Contribution to Program Outcomes

    1. Identify structure-function relationships in cells and organisms

    Method of assessment

    1. Written exam
  3. Solve analytical problems in basic and clinical immunology research

    Contribution to Program Outcomes

    1. Acquire scientific knowledge and work independently,
    2. Effectively express his/her research ideas and findings both orally and in writing

    Method of assessment

    1. Term paper
   Contents Up
Week 1: Basic concepts in immunology. The bases of innate and adaptive immunity.
Week 2: Cells and tissues of the immune system
Week 3: Circulation of cells of the immune system and theri migration into tissues.
Week 4: Innate immunity: cellular abd soluble sensors and effector molecules. Inflammation and anti-viral response. Complement system.
Week 5: Antigens and antibodies. Structure-function relationship of antibodies. The chemistry of antigen-antibody binding.
Week 6: Antigen processing in MHC Class I and II pathways. Functions of MHC Complex. Prsentation of antigens to T cells.
Week 7: Signaling through immune system and cytokine receptors
Week 8: Development of B and T lymphocytes. Mechanisms of rearrangement of antigen receptors.
Week 9: Midterm exam
Week 10: Activation of T cells. Activating signals and functional responses.
Week 11: Differentiation and functions of CD4 and CD8 T cells. Properties of effector T cells. T Cell-dependent cytotoxicity.
Week 12: Activation of B cells and antibody production.
Week 13: Humaral immune responses. Functions of antibody isotypes.
Week 14: Structure of mucosal immune system.and mucosal immune responses against pathogens.
Week 15*: General Assessment
Week 16*: Final exam
Textbooks and materials: Abul K. Abbas, Andrew H. Lichtman, & Shiv Pillai. Cellular and Molecular Immunology, 9. baskı, Elsevier (2018) ISBN: 978-0-323-52324-0
Recommended readings: Abul K. Abbas, Andrew H. Lichtman, & Shiv Pillai. Cellular and Molecular Immunology, 6. baskı, Elsevier (2007) ISBN: 9781416031222
  * Between 15th and 16th weeks is there a free week for students to prepare for final exam.
Assessment Up
Method of assessment Week number Weight (%)
Mid-terms: 8 40
Other in-term studies: 0
Project: 0
Homework: 0
Quiz: 0
Final exam: 16 60
  Total weight:
(%)
   Workload Up
Activity Duration (Hours per week) Total number of weeks Total hours in term
Courses (Face-to-face teaching): 3 14
Own studies outside class: 6 14
Practice, Recitation: 0 0
Homework: 0 0
Term project: 10 2
Term project presentation: 0 0
Quiz: 0 0
Own study for mid-term exam: 10 2
Mid-term: 3 1
Personal studies for final exam: 10 1
Final exam: 3 1
    Total workload:
    Total ECTS credits:
*
  * ECTS credit is calculated by dividing total workload by 25.
(1 ECTS = 25 work hours)
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