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Syllabus ( MBG 640 )


   Basic information
Course title: Advanced Neurobiology
Course code: MBG 640
Lecturer: Prof. Dr. Işıl KURNAZ
ECTS credits: 7.5
GTU credits: 3 (3+0+0)
Year, Semester: 2024, Fall and Spring
Level of course: Third Cycle (Doctoral)
Type of course: Area Elective
Language of instruction: English
Mode of delivery: Face to face
Pre- and co-requisites: none
Professional practice: No
Purpose of the course: Information about nervous system development, embryonic and adult neurogenesis concepts and importance of neurogenesis on learning, memory and neurodegenerative disorders; discussion of neurorestorative therapies; to enable the students to follow up-to-date techniques and publications
   Learning outcomes Up

Upon successful completion of this course, students will be able to:

  1. They can define embryonic and adult neurogenesis

    Contribution to Program Outcomes

    1. Define and manipulate advanced concepts of Biology in a specialized way
    2. Effectively express his/her research ideas and findings both orally and in writing
    3. Apply biological concepts to personal, social, economical, technological and ethical issues

    Method of assessment

    1. Written exam
    2. Homework assignment
    3. Term paper
  2. They can follow contemporary publications on neurodegenerative disorders and neurogenesis and learn about recent technologies.

    Contribution to Program Outcomes

    1. Define and manipulate advanced concepts of Biology in a specialized way
    2. Question and find out innovative approaches.
    3. Gain original, independent and critical thinking, and develop theoretical concepts and tools,
    4. Develop an awareness of continuous learning in relation with modern technology
    5. Effectively express his/her research ideas and findings both orally and in writing
    6. Apply biological concepts to personal, social, economical, technological and ethical issues

    Method of assessment

    1. Written exam
    2. Homework assignment
    3. Term paper
  3. They comprehend the correlation between learning -memory and neurogenesis.

    Contribution to Program Outcomes

    1. Define and manipulate advanced concepts of Biology in a specialized way
    2. Develop an awareness of continuous learning in relation with modern technology
    3. Effectively express his/her research ideas and findings both orally and in writing
    4. Support his/her ideas with various arguments and present them clearly to a range of audience, formally and informally through a variety of techniques
    5. Apply biological concepts to personal, social, economical, technological and ethical issues

    Method of assessment

    1. Written exam
    2. Homework assignment
    3. Term paper
   Contents Up
Week 1: Introduction to the Neuron at the Cellular and Molecular Level
Week 2: Development of the nervous system – embryonic neurogenesis
Week 3: Development of the nervous system – axon growth and guidance
Week 4: Molecular mechanisms of synaptic plasticity
Week 5: Molecular mechanisms and gene expression in LTP and LTD
Week 6: Adult neurogenic zones and adult neurogenesis
Week 7: Adult neurogenesis in learning and memory
Week 8: neural stem cell isolation and manipulation
Week 9: Neurodegenerative disorders - Alzheimer's genetics and pathology
Week 10: Neurodegenerative disorders - Parkinson's genetics and pathology
Week 11: Neurodegenerative disorders - Huntington's genetics and pathology
Week 12: Neurodegenerative disorders - ALS genetics and pathology
Week 13: Brain and spinal cord traumas
Week 14: Neural stem cell and tissue engineering approaches to traumatic brain injury
Week 15*: Term project presentations
Week 16*: Term project presentations
Textbooks and materials: • Principles of Neuroscience; Kandel, Schwartz and Jessell, McGraw Hill, 2000 (ISBN-10: 9780838577011; ISBN-13: 978-0838577011)
• Contemporary articles (as pdf files)
Recommended readings: • Principles of Neuroscience; Kandel, Schwartz and Jessell, McGraw Hill, 2000 (ISBN-10: 9780838577011; ISBN-13: 978-0838577011)
• Contemporary articles (as pdf files)
  * Between 15th and 16th weeks is there a free week for students to prepare for final exam.
Assessment Up
Method of assessment Week number Weight (%)
Mid-terms: 5 15
Other in-term studies: 9,10,11,12,13,14 60
Project: 0
Homework: 0
Quiz: 0
Final exam: 15 25
  Total weight:
(%)
   Workload Up
Activity Duration (Hours per week) Total number of weeks Total hours in term
Courses (Face-to-face teaching): 3 16
Own studies outside class: 3 16
Practice, Recitation: 0 0
Homework: 6 6
Term project: 20 1
Term project presentation: 6 1
Quiz: 0 0
Own study for mid-term exam: 6 1
Mid-term: 1 1
Personal studies for final exam: 20 1
Final exam: 1 1
    Total workload:
    Total ECTS credits:
*
  * ECTS credit is calculated by dividing total workload by 25.
(1 ECTS = 25 work hours)
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