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Syllabus ( MBG 642 )

   Basic information
Course title: Immune System In Diseases
Course code: MBG 642
Lecturer: Prof. Dr. Tamer YAĞCI
ECTS credits: 7.5
GTU credits: 3 (3+0+0)
Year, Semester: 1/2/3/4, Fall and Spring
Level of course: Third Cycle (Doctoral)
Type of course: Area Elective
Language of instruction: English
Mode of delivery: Face to face
Pre- and co-requisites: MBG 630
Professional practice: No
Purpose of the course: Students attending this course will:
-Review effector mechanisms of cell-mediated and humoral immunity
-Know inherited and acquired immune deficiency diseases.
-Grasp molecular and cellular mechanisms of allergy and hypersensitivity reactions.
-Understand pathogenic mechanisms, genetic and enviromental factors that lead to autoimmune diseases.
-Be familiar with prevention of unwanted immune responses by drugs, development of effective vaccination strategies and exploitation of immune system against tumors.
   Learning outcomes Up

Upon successful completion of this course, students will be able to:

  1. Explain main causes of inherited and acquired immune deficiencies

    Contribution to Program Outcomes

    1. Define and manipulate advanced concepts of Biology in a specialized way

    Method of assessment

    1. Written exam
  2. Distinguish molecular and cellular mechanisms between different types of allergic and hypersensitivity reactions

    Contribution to Program Outcomes

    1. Define and manipulate advanced concepts of Biology in a specialized way

    Method of assessment

    1. Written exam
    2. Term paper
  3. Apply his/her knowledge on transplantation, tumor immunology and vaccination strategies to develop innovative projects and to design experiments.

    Contribution to Program Outcomes

    1. Understand relevant research methodologies and techniques and their appropriate application within his/her research field,
    2. Gain original, independent and critical thinking, and develop theoretical concepts and tools,
    3. Find out new methods to improve his/her knowledge.

    Method of assessment

    1. Term paper
   Contents Up
Week 1: Immunologic tolerance and mechanisms of autoimmunity
Week 2: Immunity to microbes
Week 3: Strategies for vaccine development
Week 4: Transplantation immunology
Week 5: Blood groups; blood transfusion. Transplantation of hematopoetic stem cells
Week 6: Tumor immunology
Week 7: Immunotherapeutic strategies in cancer.
Week 8: Midterm exam
Week 9: Hypersensitvity gisorders. Non-IgE antibodies and T-cell mediated hypersensitivities.
Week 10: Patogenesis and therapeutic strategies in immunologic diseases: SLE, MS, Rheumatoiid arthritis, Type I diabetes mellitus.
Week 11: Allergic diseases. Genetic susceptibility, pathogenesis and therapies.
Week 12: Congenital immunodeficiencies.
Week 13: The biology of HIV and AIDS problem.
Week 14: Revision
Week 15*: Final assessment of the course
Week 16*: Final exam
Textbooks and materials: Abul K. Abbas, Andrew H. Lichtman, & Shiv Pillai. Cellular and Molecular Immunology, 9. baskı, Elsevier (2018) ISBN: 978-0-323-52324-0
Recommended readings: Murphy K, Travers P, Walport M. Immunobiology 9.. baskı Garland Science yayınları (2016) ISBN 978-0-8153-4551-0
  * Between 15th and 16th weeks is there a free week for students to prepare for final exam.
Assessment Up
Method of assessment Week number Weight (%)
Mid-terms: 8 40
Other in-term studies: 0
Project: 0
Homework: 0
Quiz: 0
Final exam: 16 60
  Total weight:
(%)
   Workload Up
Activity Duration (Hours per week) Total number of weeks Total hours in term
Courses (Face-to-face teaching): 3 14
Own studies outside class: 5 14
Practice, Recitation: 0 0
Homework: 0 0
Term project: 15 2
Term project presentation: 0 0
Quiz: 0 0
Own study for mid-term exam: 12 2
Mid-term: 3 1
Personal studies for final exam: 12 1
Final exam: 3 1
    Total workload:
    Total ECTS credits:
*
  * ECTS credit is calculated by dividing total workload by 25.
(1 ECTS = 25 work hours)
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