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Contents
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| Week 1: |
Natural products, primary and secondary metabolism
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| Week 2: |
Primary metabolites, Secondary metabolites
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| Week 3: |
The search for new bioactive metabolites
-Basic screening methodologies
-Strain improvement and process development
-Biological transformations
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| Week 4: |
Biology of antibiotic-producing microorganisms:
-Bacillus, Pseudomonas, Streptomyces, Streptoverticillium, Actinomycetes (other than Streptomyces), Myxobacteria, Aspergillus, Penicillium
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| Week 5: |
Different types of antibiotics and their mode of action
-Macrolide antibiotics
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| Week 6: |
Different types of antibiotics and their mode of action
-Poliketide antibiotics
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| Week 7: |
Different types of antibiotics and their mode of action
-Aminoglycoside antibiotics
-Beta-lactam antibiotics |
| Week 8: |
MIDTERM EXAM and evaluation |
| Week 9: |
Biosynthesis of secondary metabolites
-Class I reactions: Transformation of primary metabolites into biosynthetic intermediates
-Class II reactions: Polymerization of small metabolites
-Class III reactions: Modifications of the basic structure
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| Week 10: |
Regulation of secondary metabolite biosynthesis
-Feedback regulation
-Regulation by nutrient concentration
-Autoregulators and pleiotropic effectors
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| Week 11: |
Genetics of secondary metabolite production (Ex: Antibiotics)
-Genes for self-resistance
-Regulatory genes
-Structural biosynthetic genes
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| Week 12: |
Genetics of secondary metabolite production (Ex: Antibiotics)
-Regulatory genes
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| Week 13: |
Production of secondary metabolites
-Strain maintenance and preservation
-Fermentation technology |
| Week 14: |
Discussions of current papers related with the course |
| Week 15*: |
Discussions of current papers related with the course |
| Week 16*: |
FINAL EXAM |
| Textbooks and materials: |
Derste işlenen PDF dosyaları ve güncel yayınlar |
| Recommended readings: |
1- Biosynthesis of Secondary Metabolites - Second Edition R.B. Herbert, Springer; 2 edition (2006)
2- Secondary-Metabolite Biosynthesis and Metabolism (Environmental Science Research) Richard J. Petroski, Susan P. McCormick, Springer; 1 edition (1992)
3- Biotechnology of Antibiotics and other Bioactive Microbial Metabolites G. Lancini, R. Lorenzetti, Springer; 1 edition (1993)
4- Secondary Metabolism (Oxford Chemistry Series) J. Mann, Oxford University Press, USA; 2 edition (1987) |
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* Between 15th and 16th weeks is there a free week for students to prepare for final exam.
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