• Basic information
• Learning outcomes
• Contents
• Assessment
• Workload

Learning outcomes

Upon successful completion of this course, students will be able to:

1. Explains basic molecular mechanisms of genetic and epigenetic control.

   Contribution to Program Outcomes

   1. Define and manipulate advanced concepts of Biology
   2. Ability to work independently and take responsibility
   3. Find out new methods to improve his/her knowledge.
   4. Understand the applications and basic principles of new instrumentation and/or software vital to his/her thesis projects.
   5. Effectively express his/her research ideas and findings both orally and in writing
   6. Demonstrate professional and ethical responsibility.

   Method of assessment

   1. Written exam
2. Defines and distinguishes molecular control mechanisms that are involved in cellular signal transduction.

   Contribution to Program Outcomes

   1. Define and manipulate advanced concepts of Biology
   2. Critically review the literature pertaining to his/her research projects, and connect the earlier literature to his/her own results,
   3. Ability to work independently and take responsibility
   4. Acquire scientific knowledge and work independently,
   5. Find out new methods to improve his/her knowledge.
   6. Understand the applications and basic principles of new instrumentation and/or software vital to his/her thesis projects.
   7. Effectively express his/her research ideas and findings both orally and in writing
   8. Demonstrate professional and ethical responsibility.

   Method of assessment

   1. Written exam
   2. Homework assignment
3. Analyze mechanisms involved in genetic regulation of cellular and organismal development.

   Contribution to Program Outcomes

   1. Define and manipulate advanced concepts of Biology
   2. Find out new methods to improve his/her knowledge.
   3. Effectively express his/her research ideas and findings both orally and in writing

   Method of assessment

   1. Written exam
   2. Seminar/presentation
   3. Term paper

Contents
Week 1:	Basic principles of transcriptional regulation of gene expression, and mechanisms of genetic control.
Week 2:	Cell cycle, and its molecular regulation.
Week 3:	Small G-proteins, and regulatory cellular and molecular mechanisms.
Week 4:	Basic principles of epigenetic control.
Week 5:	Cytokine signaling.
Week 6:	miRNA forms, and their roles in development.
Week 7:	The roles of miRNAs in cancer formation and progression.
Week 8:	Midterm Examination.
Week 9:	Molecular mechanism of oncogenesis.
Week 10:	Insulin-like growth factor signaling pathway and cancer
Week 11:	Cell-cell, and cell-ECM adhesions, Rap signaling pathway, and cadherins.
Week 12:	Molecular control of telomere length in eukaryotes.
Week 13:	Protein modification by small ubiquitin-related modifiers, and their involvements in the biology of the cell.
Week 14:	Stem-cell biology
Week 15*:	Stem cell biology (continues), and IPS cell technologies.
Week 16*:	Final Examination.
Textbooks and materials:
Recommended readings:	Genes X. Lewin, B. 2010. Benjamin Cummings. Molecular Biology of The Cell. Alberts, B., et al. 2012. Garland. Signal Transduction and Human Disease. Finkel, T. and Gutkind, J.S. 2003. John Wiley & Sons. Molecular Biology of Cancer. Pecorino, L. 2005. Oxford University Press.
	* Between 15th and 16th weeks is there a free week for students to prepare for final exam.

Assessment
Method of assessment	Week number	Weight (%)
Mid-terms:	8	30
Other in-term studies:		0
Project:	10	10
Homework:	14	10
Quiz:		0
Final exam:	16	50
	Total weight:	(%)

Workload
Activity	Duration (Hours per week)	Total number of weeks	Total hours in term
Courses (Face-to-face teaching):	3	14
Own studies outside class:	3	14
Practice, Recitation:	3	1
Homework:	3	10
Term project:	2	12
Term project presentation:	1	1
Quiz:	0	0
Own study for mid-term exam:	1	8
Mid-term:	4	1
Personal studies for final exam:	2	12
Final exam:	4	1
		Total workload:
		Total ECTS credits:	*
	* ECTS credit is calculated by dividing total workload by 25. (1 ECTS = 25 work hours)